Etoricoxib Impurity 81 CAS 2241145-66-2
| CAS No. | 2241145-66-2 |
| Molecular Formula | C18H15NO4S |
| Molecular Weight | 341.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Etoricoxib Impurity 81 (CAS 2241145-66-2, C18H15NO4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Etoricoxib Impurity 81 (C18H15NO4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H15NO4S |
| Molecular Weight | 341.38 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Etoricoxib Standards
- Etoricoxib Impurity 84 (CAS CATO-C4X-108084)
- Etoricoxib Impurity 46 (CAS 2708988-48-9)
- Etoricoxib Impurity 52 (CAS CATO-C4X-108052)
- Etoricoxib Impurity 2 (CAS 316149-01-6)
- Etoricoxib Impurity 11 (CAS 2901801-70-3)
- Etoricoxib Impurity 83 (CAS CATO-C4X-108083)
- Etoricoxib Impurity 9 (CAS 202409-31-2)
- Etoricoxib Impurity 25 (CAS CATO-C4X-108025)
Recommended Standards
- Axitinib Impurity 48 (CAS 1959572-98-5)
- Trans 1-Benzyl-4-(4-fluorophenyl)-6-oxopiperidine-3-carboxylic Acid Methyl Ester (CAS 612095-72-4)
- Febuxostat Impurity 84 (CAS 2428631-65-4)
- Rosiglitazone Impurity (5-[4-N-(2-Pyridylamino)ethoxy]benzylidene] thiazolidine-2,4-dione) (CAS 643764-88-9)
- Levocarnitine Impurity 34 (CAS 93504-75-7)
- Demiditraz Impurity 3 (CAS 944263-65-4)
- Fingolimod Impurity 18 (CAS 1068-90-2)
- ethyl 1-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-1H-1,2,3-triazole-5-carboxylate (CAS 432554-68-2)
- rac-N-Methyl duloxetine, >98% (CAS 116817-11-9)
- 15816-87-2 Lanthanum, isotope of mass 138 Lanthanum-138 138La (CAS 15816-87-2)
- 2-(Isobutylcarbamoylamino)acetic acid (CAS 953742-45-5)
- 2-(2,4-Dichlorophenyl)-7-methyl-4H-thieno[3,2-d][1,3]oxazin-4-one (CAS 866151-46-4)
- 2-(Bromomethyl)-7-chlorobenzo[d]thiazole (CAS 848696-95-7)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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