Lenvatinib Impurity 135 CAS 2241758-00-7
| CAS No. | 2241758-00-7 |
| Molecular Formula | C11H8Cl2N2O2 |
| Molecular Weight | 271.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 271.10 g/mol gives Lenvatinib Impurity 135 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Lenvatinib Impurity 135 (CAS 2241758-00-7, C11H8Cl2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lenvatinib Impurity 135 (C11H8Cl2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lenvatinib Impurity 135 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8Cl2N2O2 |
| Molecular Weight | 271.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lenvatinib Standards
- Lenvatinib Impurity 107 (CAS CATO-C4X-1140107)
- Lenvatinib Impurity 150 (CAS 2713130-46-0)
- Lenvatinib Impurity 152 (CAS CATO-C4X-1140152)
- Lenvatinib Impurity 76 (CAS CATO-C4X-114076)
- Lenvatinib Impurity 109 (CAS 2852-69-9)
- Lenvatinib Impurity 134 (CAS 417723-66-1)
- Lenvatinib Impurity 15 (CAS 796848-80-1)
- Lenvatinib Impurity 178 (CAS CATO-C4X-1140178)
Recommended Standards
- (E,2E)-N-(2,4-dichlorophenyl)-2-(methoxyimino)ethanecarbohydrazonoyl cyanide 339106-75-1 9H-051 (CAS 339106-75-1)
- 321535-23-3 6-Iodo-2,3-dimethoxypyridine DTXSID60670127 (CAS 321535-23-3)
- Imibenconazole-desbenzyl-oxon (CAS 154221-27-9)
- N-(3,5-Dichlorophenyl)-5-methylisoxazole-4-carboxamide (CAS 61643-19-4)
- Lorazepam Impurity 14 (CAS CATO-C4X-104114)
- Etodolac EP Impurity B (8-Methyl Etodolac) (CAS 41340-19-6)
- Xanomeline Impurity 15 (CAS CATO-C4X-330115)
- tert-Butyl 4,4-difluoro-3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (CAS 1334413-62-5)
- Methyl (e)-3-(4-cyano-3-pyridyl)prop-2-enoate (CAS 5768-52-5)
- Ibrutinib Impurity 99 (CAS CATO-C4X-106499)
- (R)-4-Cbz-piperazine-2-carboxylic Acid (CAS 276695-09-1)
- 1-Benzyl-3,4-dibromopyrrole-2,5-dione (CAS 91026-00-5)
- 5-(Methoxymethyl)-1-methyl-1H-pyrazole (CAS 1856041-56-9)
- a2,3-Sialylglycopeptide (CAS 189035-43-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com