Clindamycin Phosphas Impurity 44 CAS 22431-46-5
| CAS No. | 22431-46-5 |
| Molecular Formula | C18H33ClN2O6S |
| Molecular Weight | 440.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Clindamycin Phosphas Impurity 44 (CAS 22431-46-5, C18H33ClN2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H33ClN2O6S, Clindamycin Phosphas Impurity 44 contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 440.98 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H33ClN2O6S |
| Molecular Weight | 440.98 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Clindamycin Standards
- Clindamycin Sulfoxide (S-Isomer) (CAS 887607-49-0)
- Clindamycin Impurity 151 (CAS CATO-C4X-1341151)
- Clindamycin Sulfoxide (R-Isomer) (CAS 887607-53-6)
- Clindamycin Impurity 47 (CAS CATO-C4X-134147)
- Clindamycin Impurity 117 (CAS CATO-C4X-1341117)
- Clindamycin Impurity 134 (CAS CATO-C4X-1341134)
- Clindamycin Impurity 59 (CAS CATO-C4X-134159)
- Clindamycin Impurity 72 (CAS CATO-C4X-134172)
Recommended Standards
- 3-((4-Chloro-N-methylphenyl)sulfonamido)-N-(2-(thiophen-2-yl)ethyl)thiophene-2-carboxamide (CAS 1251681-50-1)
- 1-((4-chlorophenyl)(phenyl)methyl)-4-tosylpiperazine (CAS 163837-56-7)
- JNJ 303 (CAS 878489-28-2)
- 2-((4-Allyl-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-chlorophenyl)acetamide (CAS 538337-08-5)
- Brexpiprazole Impurity 41 (CAS 105684-85-3)
- Maytansinoid Impurity 6 (CAS CATO-C4X-22516)
- Everolimus Impurity 33 (CAS 908340-97-6)
- 3-(4-Methoxyphenoxy)-1-methyl-1,2-dihydroquinoxalin-2-one (CAS 338774-64-4)
- n-(2-Chloroacetyl)pivalamide (CAS 735335-57-6)
- 4-Bromophenyl benzoate (CAS 1523-17-7)
- 3-Amino-3-ethylpentan-1-ol (CAS 1487552-00-0)
- 4-Nitro-n-(piperidin-4-yl)benzenesulfonamide hydrochloride (CAS 1233958-29-6)
- (3-Fluorobenzyl)hydrazine Dihydrochloride (CAS 1000805-94-6)
- Peptide YY (13-36) (canine, mouse, porcine, rat) (CAS 86895-09-2)
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