1-(2,3-Difluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole CAS 2246773-50-0
| CAS No. | 2246773-50-0 |
| Molecular Formula | C18H23BF2N2O2 |
| Molecular Weight | 348.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,3-Difluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole.
1-(2,3-Difluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (CAS 2246773-50-0) is a high-purity analytical reference standard with the molecular formula C18H23BF2N2O2 and a molecular weight of 348.20 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 1-(2,3-Difluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 348.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2,3-Difluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23BF2N2O2 |
| Molecular Weight | 348.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
- 1-(3,5-Difluoro-benzyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (CAS 1450642-72-4)
- 1,2-Difluoro-4-[2-[(trans,trans)-4'-propyl[1,1'-bicyclohexyl]-4-yl]ethyl]-benzene (CAS 107215-66-7)
- 1,2-Difluoro-4-((1S,4R)-4-(2-((1S,4S)-4-propylcyclohexyl)ethyl)cyclohexyl)benzene (CAS 117943-37-0)
- 2,6-Difluoro-N-(2-methoxyethyl)-N-(thiophen-3-ylmethyl)benzenesulfonamide (CAS 1219904-36-5)
- 2,2-Difluoro-2-phenoxy-N-[4-(trifluoromethoxy)phenyl]acetamide (CAS 338791-88-1)
- 1,3-Difluoro-2-(2-methoxy-5-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-66-7)
- 1,3-Difluoro-2-(4-methoxy-2-nitrophenoxy)-5-(trifluoromethyl)benzene (CAS 2244085-13-8)
- 2,2-Difluoro-2-(4-fluorophenoxy)-N-[3-(trifluoromethyl)phenyl]acetamide (CAS 338792-39-5)
Recommended Standards
- (2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(methylene) diacetate (CAS 2096469-96-2)
- 10-(2-Naphthyl)anthracene-9-boronic Acid (contains varying amounts of Anhydride) (CAS 597554-03-5)
- (10-(Naphthalen-1-yl)anthracen-9-yl)boronic acid (CAS 400607-46-7)
- 2-((2-((2,4-Dichloro-5-(prop-2-yn-1-yloxy)phenyl)amino)-2-oxoethyl)thio)acetic acid (CAS 339099-42-2)
- 4-(2-(Piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)morpholine (CAS 1422061-39-9)
- Rufinamide-d2 (CAS 1129491-38-8)
- n-(4-Fluoro-2-methylphenyl)-4-iodobenzamide (CAS 877954-59-1)
- tert-Butyl (4-ethynylthiazol-2-yl)carbamate (CAS 815610-14-1)
- 2-(Aminomethyl)-5-chloro-3-(difluoromethyl)-6-iodopyridine (CAS 1805172-95-5)
- 2-Methyl-4-(thiophen-3-yl)butan-1-amine (CAS 1340089-37-3)
- 5-Acetyl-1-phenyl-4,5-dihydro-1h-pyrazole-3-carboxylic acid (CAS 1240527-97-2)
- 4-Methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl trifluoromethanesulfonate (CAS 1255206-73-5)
- 1-Benzyl-3-formyl-1H-indole-2-carboxylic acid (CAS 903160-14-5)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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