Vardenafil Impurity 36 CAS 224788-36-7
| CAS No. | 224788-36-7 |
| Molecular Formula | C21H27N5O5S |
| Molecular Weight | 461.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Vardenafil Impurity 36 is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Vardenafil Impurity 36 (CAS 224788-36-7), a pharmacopoeial impurity reference standard (molecular formula C21H27N5O5S, MW 461.53 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Vardenafil Impurity 36 (C21H27N5O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 461.53 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H27N5O5S |
| Molecular Weight | 461.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2021 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Vardenafil Standards
- Vardenafil USP Related Compound E (CAS 448184-46-1)
- Vardenafil EP impurity A (CAS CATO-C4X-101722)
- Vardenafil EP Impurity A (CAS 2169247-39-4)
- Vardenafil Impurity 66 (CAS CATO-C4X-101766)
- Vardenafil Impurity N19 (CAS 2411340-39-9)
- Vardenafil Impurity 31 (CAS CATO-C4X-101731)
- Vardenafil Acetyl Analogue (CAS 1261351-28-3)
- Vardenafil Acetyl-d5 Analogue (CAS 1330171-51-1)
Recommended Standards
- STF-118804 (CAS 894187-61-2)
- 2-((4-(4-Ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide (CAS 477329-28-5)
- N-(3,4-dimethoxybenzyl)-2-(4-(4-(thiophen-2-yl)pyrimidin-2-yl)phenoxy)acetamide (CAS 477888-54-3)
- 3-(4-Ethylpiperazin-1-yl)-6-(4-((4-nitrophenyl)sulfonyl)piperazin-1-yl)pyridazine (CAS 886894-32-2)
- Netupitant Impurity 61 (CAS CATO-C4X-122361)
- Estrone Impurity N91 (CAS 474-87-3)
- Ibuprofen impurity 132 (CAS 3585-48-6)
- 8-Chloro-6-methylisoquinoline (CAS 1988725-67-2)
- 2-(1,2,4-Oxadiazol-5-yl)ethan-1-amine (CAS 1083396-12-6)
- Relebactam Impurity 54 (CAS CATO-C4X-214454)
- 1-(Pyridin-2-yl)but-3-en-1-amine (CAS 139439-03-5)
- 3-((Trimethylsilyl)oxy)propanenitrile (CAS 42202-44-8)
- (S)-3',5',6',7'-Tetrahydrospiro[cyclopropane-1,4'-imidazo[4,5-c]pyridine]-6'-carboxylic acid (CAS 1367961-56-5)
- Peptide YY (human) trifluoroacetate salt (CAS 118997-30-1)
Why CATO?
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