Vardenafil EP impurity A CAS CATO-C4X-101722
| CAS No. | CATO-C4X-101722 |
| Molecular Formula | C21H28N6O4S |
| Molecular Weight | 460.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Vardenafil EP impurity A is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Vardenafil EP impurity A (CAS CATO-C4X-101722), a pharmacopoeial impurity reference standard (molecular formula C21H28N6O4S, MW 460.55 g/mol) used for the identification and quantification of trace impurities in APIs.
Vardenafil EP impurity A (C21H28N6O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vardenafil EP impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H28N6O4S |
| Molecular Weight | 460.55 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Vardenafil Standards
- Vardenafil USP Related Compound E (CAS 448184-46-1)
- Vardenafil EP Impurity A (CAS 2169247-39-4)
- Vardenafil Impurity 66 (CAS CATO-C4X-101766)
- Vardenafil Impurity N19 (CAS 2411340-39-9)
- Vardenafil Impurity 36 (CAS 224788-36-7)
- Vardenafil Impurity 31 (CAS CATO-C4X-101731)
- Vardenafil Acetyl Analogue (CAS 1261351-28-3)
- Vardenafil Acetyl-d5 Analogue (CAS 1330171-51-1)
Recommended Standards
- N-(4-methoxyphenyl)-2-((5-(2-methoxyphenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 333313-43-2)
- N-(2-methoxyphenyl)-2-((5-(phenoxymethyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 333322-50-2)
- Sildenafil EP Impurity F (CAS 139755-82-1)
- Ethyl 6-amino-5-cyano-2-{[(3-cyano-6-ethyl-5-methylpyridin-2-yl)sulfanyl]methyl}-4-phenyl-4H-pyran-3-carboxylate (CAS 296798-03-3)
- Carbocisteine Impurity 25 (CAS CATO-C4X-201025)
- Atorvastatin Lactam Sodium Salt Impurity (CAS 148217-40-7)
- Ziprasidone Impurity 15 (CAS CATO-C4X-124015)
- 2,6-Bis((tert-butyldiphenylsilyl)oxy)anthracene-9,10-dione (CAS 159638-87-6)
- methyl 2-oxo-1H,2H,3H-pyrrolo[3,2-c]pyridine-6-carboxylate (CAS 1260386-69-3)
- Neodymium(III) chloride (CAS 10024-93-8)
- Bis(1,4-dioxa-9-azadispiro[4.1.4.3]tetradecane) oxalic acid (CAS 2007924-93-6)
- Vilanterol Impurity 88 (CAS 1582675-85-1)
- Diethyl 2-(4-chlorobutyl)malonate (CAS 18719-44-3)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
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