Vardenafil Impurity 65 CAS 224788-55-0
| CAS No. | 224788-55-0 |
| Molecular Formula | C26H36N6O5S |
| Molecular Weight | 544.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vardenafil Impurity 65 (CAS 224788-55-0) is a certified pharmaceutical impurity reference standard with the molecular formula C26H36N6O5S and a molecular weight of 544.67 g/mol.
The molecular framework of Vardenafil Impurity 65 (C26H36N6O5S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vardenafil Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H36N6O5S |
| Molecular Weight | 544.67 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2021 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Vardenafil Standards
- Vardenafil Impurity 44 (CAS CATO-C4X-101744)
- Vardenafil Impurity 61 (CAS 933796-16-8)
- Vardenafil Impurity 37 (CAS CATO-C4X-101737)
- Vardenafil Impurity 30 (CAS 1339092-18-0)
- Vardenafil Nitroso Impurity 27 (CAS CATO-C4X-101727)
- Vardenafil Impurity 33 (CAS CATO-C4X-101733)
- Vardenafil Impurity N1 (CAS 448184-56-3)
- Vardenafil Impurity 3 (CAS 224785-98-2)
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