Dacomitinib Impurity 22 CAS 2250242-14-7
| CAS No. | 2250242-14-7 |
| Molecular Formula | C8H4N4O6 |
| Molecular Weight | 252.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 252.14 g/mol gives Dacomitinib Impurity 22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Dacomitinib Impurity 22 (CAS 2250242-14-7, C8H4N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dacomitinib Impurity 22 (C8H4N4O6) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dacomitinib Impurity 22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4N4O6 |
| Molecular Weight | 252.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 4 |
Related Dacomitinib Standards
- Dacomitinib Impurity 15 (CAS CATO-C4X-208615)
- Dacomitinib Impurity 53 (CAS CATO-C4X-208653)
- Dacomitinib Impurity 23 (CAS CATO-C4X-208623)
- Dacomitinib Impurity 50 (CAS CATO-C4X-208650)
- Dacomitinib Impurity 16 (CAS CATO-C4X-208616)
- Dacomitinib Impurity 52 (CAS CATO-C4X-208652)
- Dacomitinib Impurity 17 (CAS CATO-C4X-208617)
- Dacomitinib Impurity 18 (CAS CATO-C4X-208618)
Recommended Standards
- Diclofenac impurity 10 (CAS 172494-87-0)
- 4-(Dichloroacetyl)-1-Oxa-4-Azaspiro[4,5]Decane (CAS 71526-07-3)
- 6,7-Dinitroquinoxaline-2,3-dione (CAS 2379-57-9)
- Penfluridol Impurity 14 (CAS 106392-60-3)
- Ramelteon Impurity 25 HCI (CAS 1174496-11-7)
- Lusutrombopag Impurity 73 (CAS CATO-C4X-208473)
- Ibuprofen Impurity 153 (CAS CATO-C4X-1082153)
- 2,3-Diaminopyridine (CAS 452-58-4)
- 70028-88-5 A836742 phenyl-(3,4,5-trifluorophenyl)methanone phenyl-[3,4,5-tris(fluoranyl)phenyl]methanone (CAS 70028-88-5)
- 3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-4-methyl-5-(2-(methylthio)ethyl)thiazol-3-ium chloride hydrochloride (CAS 33071-34-0)
- 5-oxo-1-(4-sulfonatophenyl)-4H-pyrazole-3-carboxylate Disodium Salt (CAS 3473-75-4)
- 3-(3-Chlorophenyl)-2',6'-dichloropropiophenone (CAS 898787-50-3)
- 1-(4-(Aminomethyl)phenyl)-2-(4-fluorophenyl)ethan-1-one hydrochloride (CAS 1187929-00-5)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com