Diclofenac impurity 10 CAS 172494-87-0
| CAS No. | 172494-87-0 |
| Molecular Formula | C13H11Cl2N |
| Molecular Weight | 252.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Diclofenac impurity 10 (CAS 172494-87-0), a pharmacopoeial impurity reference standard (molecular formula C13H11Cl2N, MW 252.14 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Diclofenac impurity 10 (C13H11Cl2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11Cl2N |
| Molecular Weight | 252.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Impurity 17 (CAS 43171-49-9)
- Diclofenac sodium Impurity 49 (CAS CATO-C4X-105149)
- Diclofenac sodium Impurity 7 (CAS 127792-34-1)
- Diclofenac Impurity 41 (CAS 131023-45-5)
- Diclofenac impurity 5 (CAS CATO-C4X-16145)
- Diclofenac impurity 6 (CAS 860541-55-5)
- Diclofenac Related Compound 14 (CAS 3644-56-2)
- Diclofenac EP Impurity B (CAS 22121-58-0)
Recommended Standards
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- Bortezomib Impurity 33 (CAS 73058-37-4)
- Ropivacaine Impurity 25 (CAS CATO-C4X-175325)
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