3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one CAS 22649-27-0
| CAS No. | 22649-27-0 |
| Molecular Formula | C10H7ClO4 |
| Molecular Weight | 226.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one (CAS 22649-27-0), molecular formula C10H7ClO4 and molecular weight 226.61 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one (C10H7ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H7ClO4 |
| Molecular Weight | 226.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
Related Chloro Standards
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Recommended Standards
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- 5-Chloro-4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 6609-39-8)
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- 2-Bromo-1-(4-(trifluoromethyl)phenyl)propan-1-one (CAS 95728-57-7)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
Why CATO?
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