2-Chloro-4,5-difluorophenol CAS 2267-98-3
| CAS No. | 2267-98-3 |
| Molecular Formula | C6H3ClF2O |
| Molecular Weight | 164.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-4,5-difluorophenol.
2-Chloro-4,5-difluorophenol (CAS 2267-98-3) is a high-purity analytical reference standard with the molecular formula C6H3ClF2O and a molecular weight of 164.54 g/mol.
Structurally, 2-Chloro-4,5-difluorophenol (C6H3ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 164.54 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-4,5-difluorophenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3ClF2O |
| Molecular Weight | 164.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-3,4-difluorophenol (CAS 1159512-40-9)
- 2-Chloro-4-(difluoromethyl)pyrimidine (CAS 1261629-31-5)
- 4-Chloro-2,3-difluorophenol (CAS 1261634-63-2)
- 4-Chloro-6-(difluoromethyl)pyrimidine (CAS 1261737-05-6)
- 2-Chloro-5-(difluoromethyl)pyrimidine (CAS 1261869-28-6)
- 4-Chloro-2,6-difluorophenol (CAS 164790-68-5)
- 6-Chloro-2,3-difluorophenol (CAS 186590-18-1)
- 5-Chloro-3,6-difluoropyridin-2-amine (CAS 189281-75-2)
Recommended Standards
- 2-Chloro-3,5-difluoropyridin-4-amine (CAS 2757677-93-1)
- 2-Chloro-4,6-difluorophenol (CAS 2267-99-4)
- 2-Chloro-3,5-difluorophenol (CAS 206986-81-4)
- 2-Choro-3,6-difluorophenol (CAS 261762-50-9)
- trans,trans-2,4-Nonadienal-d (CAS 239440-86-9)
- 3-(4-Chlorophenyl)-1,2,4-oxadiazole-5-butanoic Acid (CAS 439108-15-3)
- 7'-Methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline] (CAS 958707-54-5)
- 1-(5-Bromo-2-isopropoxyphenyl)ethan-1-one (CAS 16602-13-4)
- N-(3-(1H-Benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)-2-fluorobenzamide (CAS 825617-67-2)
- N-(1-(Indolin-1-yl)-3-methyl-1-oxopentan-2-yl)benzamide (CAS 1097624-48-0)
- 4-(4-aminopiperidin-1-yl)butanoic acid dihydrochloride (CAS 1461707-77-6)
- 3-Ethyl-[1,2,4]triazolo[4,3-a]pyridin-6-amine (CAS 1082594-12-4)
- 2-Propylpyrimidin-4-amine (CAS 100910-69-8)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com