2-Chloro-4,6-difluorophenol CAS 2267-99-4
| CAS No. | 2267-99-4 |
| Molecular Formula | C6H3ClF2O |
| Molecular Weight | 164.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Chloro-4,6-difluorophenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-Chloro-4,6-difluorophenol (CAS 2267-99-4) is a high-purity analytical reference standard with the molecular formula C6H3ClF2O and a molecular weight of 164.54 g/mol.
Based on its molecular formula C6H3ClF2O, 2-Chloro-4,6-difluorophenol contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 164.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H3ClF2O |
| Molecular Weight | 164.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-3,4-difluorophenol (CAS 1159512-40-9)
- 2-Chloro-4-(difluoromethyl)pyrimidine (CAS 1261629-31-5)
- 4-Chloro-2,3-difluorophenol (CAS 1261634-63-2)
- 4-Chloro-6-(difluoromethyl)pyrimidine (CAS 1261737-05-6)
- 2-Chloro-5-(difluoromethyl)pyrimidine (CAS 1261869-28-6)
- 4-Chloro-2,6-difluorophenol (CAS 164790-68-5)
- 6-Chloro-2,3-difluorophenol (CAS 186590-18-1)
- 5-Chloro-3,6-difluoropyridin-2-amine (CAS 189281-75-2)
Recommended Standards
- 2-Chloro-4,5-difluorophenol (CAS 2267-98-3)
- 2-Choro-3,6-difluorophenol (CAS 261762-50-9)
- 2-Chloro-3,5-difluoropyridin-4-amine (CAS 2757677-93-1)
- 3-Chloro-2,4-difluorophenol (CAS 2268-00-0)
- 3-Methoxy-1H-pyrrole-2-carbonitrile (CAS 54764-97-5)
- 17α-Methyl-4-[(phenylthio)methyl]testosterone (CAS 71507-77-2)
- 5-(2,6-dichlorophenoxymethyl)-1,2-oxazole-3-carboxylic acid (CAS 1225900-23-1)
- 4-(3-((4-(4-Bromophenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acrylamido)benzamide (CAS 477330-09-9)
- 5-Bromo-4-cyano-2-(difluoromethyl)benzoic acid (CAS 1805592-21-5)
- N-Benzyl-N-isopropyl-2-methoxybenzamide (CAS 552854-67-8)
- 1-(2-(6-(Dimethylamino)-4-methylpyridin-3-yl)pyrrolidin-1-yl)ethanone (CAS 1352523-20-6)
- 6-Methyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine (CAS 123792-64-3)
- ethyl 3-(acetylamino)-1H-indole-2-carboxylate (CAS 56545-51-8)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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