Riluzole Impurity 27 CAS 2273706-77-5
| CAS No. | 2273706-77-5 |
| Molecular Formula | C8H4ClF3N2OS |
| Molecular Weight | 268.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Riluzole Impurity 27 (CAS 2273706-77-5, C8H4ClF3N2OS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Riluzole Impurity 27 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 268.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Riluzole Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF3N2OS |
| Molecular Weight | 268.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Riluzole Standards
- Riluzole Impurity 26 (CAS CATO-C4X-200926)
- Riluzole Impurity 17 (CAS CATO-C4X-200917)
- Riluzole Impurity 25 (CAS 442665-84-1)
- Riluzole Impurity 7 (CAS 1456696-94-8)
- Riluzole Impurity 6 (CAS 179070-90-7)
- Riluzole Impurity 14 (CAS CATO-C4X-200914)
- Riluzole-13C,15N2 (CAS 1215552-03-6)
- Riluzole Impurity 3 (CAS 142229-74-1)
Recommended Standards
- 3-Chloro-2',4'-difluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 505082-89-3)
- 2-[4-(chlorosulfonyl)-2-fluorophenoxy]acetic acid (CAS 1016737-75-9)
- Ethyl 4,4,4-trifluoro-3-sulfobutanoate (CAS 1803598-32-4)
- 1-(4-Chloro-3-nitrobenzyl)pyrrolidine-2,5-dione (CAS 1097788-45-8)
- Eravacycline impurity 25 (CAS CATO-C4X-293825)
- Quinocide (Primaquine EP Impurity A) (CAS 525-61-1)
- Pregabalin impurity 02 (CAS 501666-23-5&501666-24-6)
- N-(5-Amino-2-methoxyphenyl)cyclopentanecarboxamide (CAS 926269-06-9)
- 3-Bromo-4-chloro-8-methoxyquinoline (CAS 142781-92-8)
- 3-Methoxythiophene-2-carbonyl chloride (CAS 54450-14-5)
- Ethyl 4-amino-5-chloro-8-methoxyquinoline-3-carboxylate (CAS 1242260-66-7)
- 2-(Bicyclo[2.1.1]hexan-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2609867-47-0)
- 2,4-Dichloro-7-(4-fluorophenyl)-7-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine (CAS 1356010-00-8)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
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