Ethyl 3,3-Difluoro-1-methylcyclobutanecarboxylate CAS 227607-45-6
| CAS No. | 227607-45-6 |
| Molecular Formula | C8H12F2O2 |
| Molecular Weight | 178.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ethyl 3,3-Difluoro-1-methylcyclobutanecarboxylate (CAS 227607-45-6) is a high-purity analytical reference standard with the molecular formula C8H12F2O2 and a molecular weight of 178.18 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Ethyl 3,3-Difluoro-1-methylcyclobutanecarboxylate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 178.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12F2O2 |
| Molecular Weight | 178.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | F-containing |
Related Ethyl Standards
- 2,2-Difluoro-1-(4-methylpiperazin-1-yl)ethanone (CAS 121412-30-4)
- 4,4-Difluoro-1-methylcyclohexane-1-carboxylic acid (CAS 1389313-41-0)
- 6,8-difluoro-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS 1643856-61-4)
- 8,8-Difluoro-1,4-dioxaspiro[4.5]decane (CAS 176251-49-3)
- 2-Ethyl-4,4-difluoro-2-hydroxycyclohexan-1-one (CAS 2839564-79-1)
- 4,4-Difluoro-2-methoxy-2-methylcyclohexan-1-one (CAS 2839564-85-9)
- 4,4-Difluoro-6,6-dimethyltetrahydro-2H-pyran-2-carbaldehyde (CAS 2791313-73-8)
- 2,2-Difluoro-2-(1,3-thiazol-2-yl)acetamide (CAS 1850835-10-7)
Recommended Standards
- Ethyl 3-(difluoromethyl)cyclobutane-1-carboxylate (CAS 2120250-04-4)
- Ethyl 3-formylbenzoate (CAS 33745-47-0)
- Ethyl 2-formylbenzoate (CAS 34046-43-0)
- Ethyl β-D-xylopyranoside (CAS 6743-62-0)
- N-Boc-dolaproine (CAS 120205-50-7)
- N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-ethyl-11-oxo-5H,5aH,6H,7H,8H,9H,11H-pyrido[2,1-b]quinazoline-3-carboxamide (CAS 1574605-71-2)
- 5-Phenyl-1-(p-tolyl)-1H-1,2,4-triazole-3-carboxylic acid (CAS 94066-24-7)
- 6-(4-Methoxyphenyl)-5-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazole (CAS 681260-16-2)
- Lufenuron (CAS 103055-07-8)
- 2,6-Diethylaniline (CAS 579-66-8)
- 5-(4-Fluorophenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 675830-44-1)
- 3753-81-9 1XMW35DTHB 1,3-Bis(4-carboxyphenoxy)propane Benzoic acid, 4,4'-(1,3-propanediylbis(oxy))bis- 1,3-Bis(p-carboxyphenoxy)propane 1,3-Bis-cpp Cpp-bis 4,4'-(1,3-Propanediylbis(oxy))bis-benzoic acid 4,4'-(Trimethylenedioxy)di-benzoic acid UNII-1XMW35DTHB (CAS 3753-81-9)
- 1-(2,4-Diamino-7-methyl-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)ethanone (CAS 1854-51-9)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com