Citalopram Impurity 22 CAS 227954-87-2
| CAS No. | 227954-87-2 |
| Molecular Formula | C20H22FNO2 |
| Molecular Weight | 327.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Citalopram Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Citalopram Impurity 22 (CAS 227954-87-2) is a certified pharmaceutical impurity reference standard with the molecular formula C20H22FNO2 and a molecular weight of 327.39 g/mol.
Citalopram Impurity 22 (C20H22FNO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H22FNO2 |
| Molecular Weight | 327.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Citalopram Standards
- Citalopram Impurity 64 (CAS CATO-C4X-110964)
- Citalopram-d4 (CAS 1219908-84-5)
- Citalopram Impurity 17 (CAS 1187671-15-3)
- Citalopram Impurity N1 (CAS 920282-75-3)
- Citalopram EP Impurity I (Mixture of Z and E Isomers) (CAS CATO-C4X-110918)
- (S)-Citalopram (CAS 128196-01-0)
- Citalopram (CAS 59729-33-8)
- Citalopram-d6 (CAS 1190003-26-9)
Recommended Standards
- Ethyl 1-benzyl-4-(4-fluorophenyl)pyrrolidine-3-carboxylate (CAS 874990-58-6)
- 4-Hydroxy-1-((2,3,5,6-tetramethylphenyl)sulfonyl)pyrrolidine-2-carboxylic acid (CAS 1008981-54-1)
- Ethyl 1-benzyl-4-(2-fluorophenyl)pyrrolidine-3-carboxylate (CAS 874990-49-5)
- 1-(4-tert-Butyl-benzenesulfonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid (CAS 1009529-98-9)
- Epalrestat Impurity 58 (CAS 44912-47-2)
- Flumazenil (N-[11C]Methyl) EP Impurity A (CAS 79089-72-8)
- Aceclidine Impurity 3 (CAS 13929-94-7)
- 1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester hydrochloride (CAS 1187929-10-7)
- 3-Methylphenyl 3-(1-piperazinyl)propyl ether (CAS 401802-29-7)
- 6-Methoxy-3,4-dihydronaphthalen-1(2H)-one oxime (CAS 54951-36-9)
- 2-Isopropoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 1572455-46-9)
- Tributyltin acetate (CAS 56-36-0)
- Hydroxychloroquine impurity 78 (CAS CATO-C4X-183578)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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