Tofacitinib Impurity N49 CAS 2280085-84-7
| CAS No. | 2280085-84-7 |
| Molecular Formula | C30H41N11O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tofacitinib Impurity N49 (CAS 2280085-84-7) is a certified pharmaceutical impurity reference standard with the molecular formula C30H41N11O2HCl and a molecular weight of 624.19 g/mol.
Tofacitinib Impurity N49 (C30H41N11O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H41N11O2 HCl |
| Molecular Weight | 624.19 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 11 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
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- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
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Recommended Standards
- Picosulfate Impurity 32 (CAS CATO-C4X-123732)
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- Fmoc-2-fluoro-L-homophenylalanine (CAS 1260587-53-8)
- 2-Chloro-3-(difluoromethoxy)-1,4-difluoro-benzene (CAS 1261869-12-8)
- (E)-4-Bromo-2-((pyridin-2-ylimino)methyl)phenol (CAS 17543-99-6)
- (6-Chloro-[1,3]dioxolo[4,5-g]quinolin-7-ylmethyl)-cyclopentylmethyl-amine (CAS 1000347-99-8)
- 265108-40-5 4-[(2-Ethoxyethoxy)methyl]piperidine 8769AD C10H21NO2 (CAS 265108-40-5)
- Hexapeptide-9 (CAS 1228371-11-6)
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