3-(2,2-difluorocyclopropyl)prop-2-ynoic acid CAS 2293250-95-8
| CAS No. | 2293250-95-8 |
| Molecular Formula | C6H4F2O2 |
| Molecular Weight | 146.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 146.09 g/mol gives 3-(2,2-difluorocyclopropyl)prop-2-ynoic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-(2,2-difluorocyclopropyl)prop-2-ynoic acid (CAS 2293250-95-8) is a high-purity analytical reference standard with the molecular formula C6H4F2O2 and a molecular weight of 146.09 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(2,2-difluorocyclopropyl)prop-2-ynoic acid is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 146.09 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4F2O2 |
| Molecular Weight | 146.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
Related difluorocyclopropyl Standards
- 3-(2,2-Difluorocyclopropyl)pyrrolidine (CAS 2098109-82-9)
- 3-(2,2-Difluorocyclopropyl)propanoic acid (CAS 1955499-07-6)
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- 4-(2,2-Difluorocyclopropyl)-1-Butanol (CAS 143952-26-5)
- (2,2-Difluorocyclopropyl)benzene (CAS 13343-40-3)
- 2-(2,2-difluorocyclopropyl)acetic acid (CAS 123131-67-9)
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- 4-(2,2-Difluorocyclopropyl)piperidine (CAS 2092725-85-2)
Recommended Standards
- 2,6-Difluorobenzene-1,4-diol (CAS 84959-65-9)
- 3,4-Difluoro-6-methyl-2H-pyran-2-one (CAS 75599-88-1)
- 2,5-Difluorobenzene-1,4-diol (CAS 367-35-1)
- 3,6-Difluorobenzene-1,2-diol (CAS 75626-23-2)
- 2-[(1-Phenyl-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide (CAS 181421-72-7)
- 3-(2,3-Dimethylphenyl)-2-thiomethylpropiophenone (CAS 898769-29-4)
- Fmoc-l-2,4,5-trifluorophenylalanine (CAS 959579-81-8)
- 1-(Tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (CAS 2306260-70-6)
- 4-Methoxy-2-methylpyridine (CAS 24103-75-1)
- 4-(4-((4,4-Dimethyl-4,5-dihydrooxazol-2-yl)methyl)phenyl)but-3-en-1-ol (CAS 60341-01-7)
- 2,2,7,7-Tetra([1,1'-biphenyl]-4-yl)-2,7-dihydro-9,9'-spirobi[fluorene] (CAS 171408-93-8)
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