Vonoprazan Impurity 148 CAS 2304978-51-4
| CAS No. | 2304978-51-4 |
| Molecular Formula | C11H7FN2O |
| Molecular Weight | 202.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Vonoprazan Impurity 148 (CAS 2304978-51-4) is a certified pharmaceutical impurity reference standard with the molecular formula C11H7FN2O and a molecular weight of 202.18 g/mol.
Based on its molecular formula C11H7FN2O, Vonoprazan Impurity 148 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 202.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H7FN2O |
| Molecular Weight | 202.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Vonoprazan Standards
- Vonoprazan Fumarate impurity 1 (CAS 312307-38-3)
- Vonoprazan Impurity 147 (CAS 748810-25-5)
- Vonoprazan Impurity 150 (CAS 312307-69-0)
- Vonoprazan Impurity 308 (CAS CATO-C4X-1020308)
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- Vonoprazan Impurity 262 (CAS CATO-C4X-1020262)
- Vonoprazan Impurity 217 (CAS 16420-39-6)
Recommended Standards
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- Ixazomib Impurity 68 (CAS 121-53-9)
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- (R)-2-(Piperidin-2-yl)ethanamine (CAS 1262326-82-8)
- 4-Cyano-3-(difluoromethyl)-5-fluoropyridine-2-acetic acid (CAS 1806874-76-9)
- n-Tetradecane-d30 (CAS 204244-81-5)
- 2,6-Dimethyl-4-(6-phenylhexyl)morpholine (CAS 101807-59-4)
- 4-Bromofuran-3-carbaldehyde (CAS 164513-46-6)
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