3,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid CAS 2308530-30-3
| CAS No. | 2308530-30-3 |
| Molecular Formula | C22H12F6O4 |
| Molecular Weight | 454.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid (C22H12F6O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
3,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid (CAS 2308530-30-3) is a high-purity analytical reference standard with the molecular formula C22H12F6O4 and a molecular weight of 454.32 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H12F6O4 |
| Molecular Weight | 454.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
Related Bis Standards
- 4-[3,5-Bis(trifluoromethyl)benzoyl]-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326815-18-2)
- 4-((2-Oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)-N-(3-(trifluoromethyl)benzyl)benzamide (CAS 339025-40-0)
- 1-Benzyl-3'-(3-(trifluoromethyl)phenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione (CAS 338418-99-8)
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- 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid (CAS 1076197-34-6)
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Recommended Standards
- 3-(3-Bromo-4,5-dimethoxyphenyl)-6-(pyrrolidin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine (CAS 87540-18-9)
- (E)-1-((4-bromo-3-methylphenyl)amino)-4-((2-fluoro-[1,1'-biphenyl]-4-yl)oxy)pent-1-en-3-one (CAS 477888-51-0)
- 4-[5-(2,4-Dichlorophenyl)-1H-pyrazol-3-yl]-1-{[3-(trifluoromethyl)phenyl]methyl}piperidine (CAS 1025724-79-1)
- 2-Chloro-N-(2-chlorobenzoyl)-N-[4-(thiophen-2-yl)pyrimidin-2-yl]benzamide (CAS 866144-00-5)
- 3-bromoimidazo[1,2-a]pyridin-7-amine (CAS 1092352-46-9)
- 3-[2-(diisopropylamino)ethyl]-2-mercaptoquinazolin-4(3H)-one (CAS 730951-04-9)
- 2-Chloro-n-[4-(2,4,5-trimethylphenyl)-1,3-thiazol-2-yl]acetamide (CAS 733796-12-8)
- Fmoc-3-(4-Quinolyl)-L-Ala-OH (CAS 1998513-62-4)
- 1-Carbamoylcyclopentane-1-carboxylic acid (CAS 137307-52-9)
- 2-Cyano-3-(difluoromethyl)-4-methylbenzoic acid (CAS 1807299-19-9)
- 3-O-α-L-Fucopyranosyl-D-galactose (CAS 24667-49-0)
- 2-(3-Amino-1h-pyrazol-1-yl)-n-(2-methoxyethyl)acetamide (CAS 1249908-86-8)
- Metoclopramide Impurity 31 (CAS CATO-C4X-141531)
- Tirzepatide Impurity 1 (CAS 2460751-66-8)
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