Donepezil EP Impurity E Bromide CAS 231283-82-2
| CAS No. | 231283-82-2 |
| Molecular Formula | C24H24NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Donepezil EP Impurity E Bromide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Donepezil EP Impurity E Bromide (CAS 231283-82-2) is a certified pharmaceutical impurity reference standard with the molecular formula C24H24NO3Br and a molecular weight of 454.36 g/mol.
The molecular framework of Donepezil EP Impurity E Bromide (C24H24NO3Br) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H24NO3 Br |
| Molecular Weight | 454.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2023 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil Impurity 15 (CAS 1023500-88-0)
- Donepezil Impurity 44 (CAS 1026443-48-0)
- Donepezil Impurity 46 (CAS 1034439-43-4)
- Donepezil-d5 (CAS 1128086-25-8)
- Donepezil Impurity 55 (CAS 1189443-74-0 (free base))
- Donepezil Related Compound A HCl (CAS 120011-69-0)
- Donepezil Hydrochloride (CAS 120011-70-3)
- Donepezil Impurity 25 (CAS 120012-04-6)
Recommended Standards
- Niraparib Impurity 50 (CAS CATO-C4X-232950)
- Tadalafil Impurity 17 (CAS 629652-42-2)
- Arbidol Impurity 57 (CAS CATO-C4X-112957)
- 1-Methyl-4-((thietan-3-ylamino)methyl)piperidin-4-ol (CAS 1863314-19-5)
- 2-(2-Chloroethoxy)ethanamine (CAS 95239-78-4)
- (R)-2-amino-3-(5-bromo-2-methoxyphenyl)propanoic acid (CAS 1270185-65-3)
- 6-Amino-3-iodo-5-nitro-1h-pyridin-2-one (CAS 642460-96-6)
- 1,1,1-Trichloro-13,16,19,22-tetraoxa-1-silatricosane (CAS 219641-32-4)
- 3-Ethylcyclobutanone (CAS 56335-73-0)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com