Tadalafil Impurity 17 CAS 629652-42-2
| CAS No. | 629652-42-2 |
| Molecular Formula | C22H19ClN2O5 |
| Molecular Weight | 426.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Tadalafil Impurity 17 (C22H19ClN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 426.85 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Tadalafil Impurity 17 (CAS 629652-42-2, C22H19ClN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H19ClN2O5 |
| Molecular Weight | 426.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil impurity 10 (CAS 629652-40-0)
- Tadalafil Impurity 16 (CAS 629652-44-4)
- Tadalafil Impurity 37 (CAS 171489-59-1)
- Tadalafil Impurity 67 (CAS CATO-C4X-108767)
- Tadalafil Impurity 84 (CAS CATO-C4X-108784)
- Tadalafil Impurity N23 (CAS 951661-84-0)
- Tadalafil Impurity 24 (CAS 951661-81-7)
- Tadalafil Impurity 70 (CAS CATO-C4X-108770)
Recommended Standards
- Ethyl 2-amino-4-(4-chlorophenyl)-5-cyano-6-oxo-1-((6-oxocyclohex-1-en-1-yl)amino)-1,6-dihydropyridine-3-carboxylate (CAS 341965-82-0)
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- 5-Bromo-2-methylquinoline (CAS 54408-52-5)
- 1,3-Cyclohexanedione, 2-(cyclopropylcarbonyl)- (CAS 288258-62-8)
- 2-(2-Formyl-1H-pyrrol-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (CAS 352553-63-0)
- Isopropyl 4-Hydroxypiperidine-1-carboxylate (CAS 832715-51-2)
- 8-(Benzo[d]oxazol-2-yl)-8-azabicyclo[3.2.1]Octan-3-ol (CAS 1483427-22-0)
- Ethyl 2,6-dimethyl-4-oxocyclohexanecarboxylate (CAS 36714-68-8)
- Osteoblast-Adhesive Peptide (CAS 193613-75-1)
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