Sunitinib Impurity 63 CAS 2343-22-8
| CAS No. | 2343-22-8 |
| Molecular Formula | C8H8FN |
| Molecular Weight | 137.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sunitinib Impurity 63.
Sunitinib Impurity 63 (CAS 2343-22-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8FN and a molecular weight of 137.15 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Sunitinib Impurity 63 is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 137.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sunitinib Impurity 63 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8FN |
| Molecular Weight | 137.15 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Sunitinib Standards
- Sunitinib Impurity 4 (CAS 17106-13-7)
- Sunitinib Impurity 86 (CAS 90433-88-8)
- Sunitinib Impurity 62 (CAS CATO-C4X-133362)
- Sunitinib Impurity 16 (CAS 56341-41-4)
- Sunitinib Impurity 46 (CAS 138343-94-9)
- Sunitinib Impurity 47 (CAS 56341-39-0)
- Sunitinib Impurity 48 (CAS 71294-03-6)
- Sunitinib Impurity 87 (CAS 1032268-12-4)
Recommended Standards
- 6-Fluoro-2,3-Dihydro-1H-Indole (CAS 2343-23-9)
- Ethyl-d5-Malonic Acid (CAS 66311-22-6)
- 5-Fluoroisoindoline (CAS 57584-71-1)
- (S)-4-Methyl-1,2,3-oxathiazolidine 2,2-dioxide (CAS 1025505-82-1)
- Cefcapene Impurity 71 (CAS CATO-C4X-182471)
- Clopidogrel Impurity 14 (CAS 5402-55-1)
- Gadobutrol impurity 160 (CAS CATO-C4X-2120160)
- Methyl(S)-3-(4-(benzyloxy)phenyl)-2-hydroxypropanoate (CAS 481072-37-1)
- 2'-((7-Methoxy-9H-fluoren-2-yl)carbamoyl)-[1,1'-biphenyl]-2-carboxylic acid (CAS 25663-06-3)
- 1-(4-Amino-2-chloropyrimidin-5-yl)ethanone (CAS 909562-67-0)
- 5-Nitro-2-(4-phenylpiperazin-1-yl)benzaldehyde (CAS 871807-34-0)
- 3-Amino-6-ethyl-N-[(2-methoxyphenyl)methyl]-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide (CAS 445268-91-7)
- 2-Cyclopentylquinazolin-4-amine (CAS 1264037-72-0)
- Peptide Impurity 05 (CAS 2322924-83-2)
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