Sunitinib Impurity 48 CAS 71294-03-6
| CAS No. | 71294-03-6 |
| Molecular Formula | C8H6FNO |
| Molecular Weight | 151.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Sunitinib Impurity 48 (C8H6FNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 151.14 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Sunitinib Impurity 48 (CAS 71294-03-6, C8H6FNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sunitinib Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6FNO |
| Molecular Weight | 151.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Sunitinib Standards
- Sunitinib Impurity 16 (CAS 56341-41-4)
- Sunitinib Impurity 46 (CAS 138343-94-9)
- Sunitinib Impurity 47 (CAS 56341-39-0)
- Sunitinib Impurity 87 (CAS 1032268-12-4)
- Sunitinib Impurity 62 (CAS CATO-C4X-133362)
- Sunitinib Impurity 86 (CAS 90433-88-8)
- Sunitinib Impurity 4 (CAS 17106-13-7)
- Sunitinib Impurity 45 (CAS 443-69-6)
Recommended Standards
- Trelagliptin Impurity N5 (CAS 1000339-93-4)
- (3,5-difluoropyridin-2-yl)methanol (CAS 1065267-14-2)
- Olaparib Impurity 67 (CAS 227609-85-0)
- (1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol (CAS 1109284-40-3)
- Azelastine EP Impurity E (Z-Isomer) (CAS 105279-16-1)
- Etonogestrel Impurity 1 (CAS 947193-18-2)
- Desmopressin Impurity 29 (CAS CATO-C4X-221529)
- Paliperidone impurity 146 (CAS CATO-C4X-1724146)
- 4-(4-Hydroxypiperidin-1-yl)benzimidamide (CAS 887577-50-6)
- Sodium 5-butylbenzo[d][1,2,3]triazol-1-ide (CAS 118685-34-0)
- Methyl 1-(difluoromethyl)-3-methyl-1H-pyrazole-5-carboxylate (CAS 2540502-93-8)
- (2S,3S)-3-Methyl-2-(methylamino)pentanoic acid hydrochloride (CAS 66866-68-0)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-(4-(4-methoxyphenyl)piperazin-1-yl)ethan-1-one (CAS 692737-09-0)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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