N1-Nitroso Tryptophan EP Impurity I CAS 23708-74-9
| CAS No. | 23708-74-9 |
| Molecular Formula | C13H13N3O3 |
| Molecular Weight | 259.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N1-Nitroso Tryptophan EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N1-Nitroso Tryptophan EP Impurity I (CAS 23708-74-9) is a certified pharmaceutical impurity reference standard with the molecular formula C13H13N3O3 and a molecular weight of 259.26 g/mol.
The molecular framework of N1-Nitroso Tryptophan EP Impurity I (C13H13N3O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H13N3O3 |
| Molecular Weight | 259.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 3 |
Related N Standards
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Recommended Standards
- 3989-13-7 Benzene,1-bromo-3-[2-(trimethylsilyl)ethynyl]- CTK4I2053 (CAS 3989-13-7)
- Regorafenib Impurity 40 (CAS CATO-C4X-104740)
- ((2-bromophenyl)ethynyl)trimethylsilane (2-Bromophenylethynyl)trimethylsilane 38274-16-7 (CAS 38274-16-7)
- Regorafenib Impurity 48 (CAS CATO-C4X-104748)
- Canagliflozin Impurity 35 (CAS 1951467-28-9)
- Mesalazine Impurity 25 (CAS 42753-75-3)
- Darolutamide impurity 10 (CAS 1976022-48-6)
- 3-Ethynyl-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1189793-01-8)
- 2,4-Difluoro-5-nitrobenzonitrile (CAS 67152-20-9)
- 3-[(2-methylpropane-2-sulfinyl)methyl]aniline (CAS 28288-33-7)
- Metolachlor mercapturate (CAS 159956-64-6)
- 1-Benzyl-1-methylpiperidin-1-ium chloride (CAS 13127-28-1)
- N-Nitroso Nipecotic Acid-d (CAS 1329834-25-4)
- [y-Glu3]-Semaglutide Impurity 135 (CAS CATO-C4X-2226135)
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