3-[(tert-Butyldimethylsilyl)oxy]-2-chloro-6-fluorophenylboronic acid CAS 2377611-81-7
| CAS No. | 2377611-81-7 |
| Molecular Formula | C12H19BClFO3Si |
| Molecular Weight | 304.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
3-[(tert-Butyldimethylsilyl)oxy]-2-chloro-6-fluorophenylboronic acid (CAS 2377611-81-7) is a high-purity analytical reference standard with the molecular formula C12H19BClFO3Si and a molecular weight of 304.63 g/mol.
The molecular framework of 3-[(tert-Butyldimethylsilyl)oxy]-2-chloro-6-fluorophenylboronic acid (C12H19BClFO3Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H19BClFO3Si |
| Molecular Weight | 304.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
Related tert Standards
- tert-butyldimethylsilyl 2-[(tert-butyldimethylsilyl)oxy]acetate (CAS 67226-76-0)
- 5-((Tert-butyldimethylsilyl)oxy)-7-methoxynaphthalen-2-ol (CAS 2205058-60-0)
- 1-(2-(((Tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridin-6-yl)ethan-1-one (CAS 1203499-37-9)
- ((Tert-butyldimethylsilyl)imino)(difluoromethyl)(phenyl)-λ6-sulfanone (CAS 1402352-49-1)
- 7-((tert-butyldimethylsilyl)oxy)-N-methoxy-N-methylheptanamide (CAS 2007908-84-9)
- {8-[(tert-butyldimethylsilyl)oxy]quinolin-7-yl}boronic acid (CAS 1486485-32-8)
- (3-((Tert-butyldimethylsilyl)oxy)-2,4,6-trifluorophenyl)boronic acid (CAS 1072946-65-6)
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Recommended Standards
- 3-(t-Butyldimethylsilyloxy)-4-chloro-2-fluorophenylboronic acid (CAS 1256354-94-5)
- 4-(tert-Butyldimethylsilyloxy)-3-chloro-2-fluorophenylboronic acid (CAS 2377608-26-7)
- 2,2,3,3,9,9,10,10-Octamethyl-4,8-dioxa-3,9-disilaundecane (CAS 82112-22-9)
- 5-(Chlorosulfonyl)-2-(trifluoromethoxy)benzoic acid (CAS 845616-29-7)
- 1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-1H-indazole (CAS 1454301-68-8)
- 3-Bromo-5-nitro-[1,1'-biphenyl]-4-amine (CAS 136649-25-7)
- N-(3,4-Dichlorophenyl)-3-{[(4-nitrobenzyl)oxy]imino}propanamide (CAS 477851-53-9)
- 4-Cyano-3-fluorophenyl (1r,1's,4R,4'R)-4'-pentyl-[1,1'-bi(cyclohexane)]-4-carboxylate (CAS 94353-27-2)
- Nafamostat Impurity 15 (CAS 6306-25-8)
- [1-(2-methylpropyl)-1H-imidazol-2-yl]methanamine (CAS 1216209-29-8)
- 4-Methoxyfuro[2,3-b]pyridine (CAS 193624-92-9)
- 8-Bromo-1,2-difluoro-6-(methoxymethoxy)naphthalene (CAS 2791271-62-8)
- 2-Chloro-4-ethyl-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile (CAS 1708251-17-5)
- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
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