4-Chloro-8-(trifluoromethyl)quinoline CAS 23779-97-7
| CAS No. | 23779-97-7 |
| Molecular Formula | C10H5ClF3N |
| Molecular Weight | 231.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 4-Chloro-8-(trifluoromethyl)quinoline (C10H5ClF3N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 231.60 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 4-Chloro-8-(trifluoromethyl)quinoline (CAS 23779-97-7), a certified reference material (molecular formula C10H5ClF3N, MW 231.60 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3N |
| Molecular Weight | 231.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-Chloro-7-(trifluoromethyl)quinoline (CAS 104612-21-7)
- 6-Chloro-8-(trifluoromethyl)quinoline (CAS 1065074-68-1)
- 1-chloro-6-(trifluoromethyl)isoquinoline (CAS 1196152-92-7)
- 1-Chloro-7-(trifluoromethyl)isoquinoline (CAS 1196154-02-5)
- 4-Chloro-3-nitrotrifluorotoluene (CAS 121-17-5)
- 8-Chloro-6-(trifluoromethyl)quinoline (CAS 1215206-39-5)
- 1-Chloro-8-trifluoromethyl-isoquinoline (CAS 1283719-92-5)
- 3-Chloro-6-(trifluoromethyl)isoquinoline (CAS 1357945-78-8)
Recommended Standards
- 4-chloro-6,7,8-trifluoro-2-methylquinoline (CAS 951905-11-6)
- 2-Chloro-5-nitrobenzotrifluoride 5-nitro-2-chlorobenzotrifluoride 2-chloro-a,a,a-trifluoro-5-nitrotoluene 2-chloro-5-nitro-a,a,a-trifluorotoluene 1-chloro-4-nitro-2-trifluoromethyl-benzene 2-chloro-5-nitro benzotrifluoride 2-chloro-5-nitro-alpha,alpha,alpha-trifluorotoluene 1-chloro-2-(trifluoromethyl)-4-nitrobenzene 4-chloro-3-(trifluoromethyl)nitrobenzene 1-chloro-4-nitro-2-(trifluoromethyl)benzene 777-37-7 (CAS 777-37-7)
- 4-Chloro-6-(trifluoromethyl)quinoline (CAS 49713-56-6)
- 2-Chloro-5-(trifluoromethyl)quinoline (CAS 886761-95-1)
- n-(2-Cyanoethyl)-4-ethyl-N-methyl-1,2,3-thiadiazole-5-carboxamide (CAS 1252183-43-9)
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