Bortezomib Impurity 30 CAS 2379402-85-2
| CAS No. | 2379402-85-2 |
| Molecular Formula | C19H22N4O4 |
| Molecular Weight | 370.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bortezomib Impurity 30 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Bortezomib Impurity 30 (CAS 2379402-85-2, C19H22N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H22N4O4, Bortezomib Impurity 30 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 370.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22N4O4 |
| Molecular Weight | 370.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 4 |
Related Bortezomib Standards
- Bortezomib Impurity 19 (CAS CATO-C4X-107219)
- Bortezomib Impurity 52 (CAS CATO-C4X-107252)
- Bortezomib Impurity 65 (CAS CATO-C4X-107265)
- Bortezomib Impurity 14 (CAS CATO-C4X-107214)
- Bortezomib Impurity 15 (CAS CATO-C4X-107215)
- Bortezomib Impurity 8 (CAS 886979-81-3)
- Bortezomib Impurity 9 (CAS 886979-78-8)
- Bortezomib Impurity 15 (CAS 275374-67-9)
Recommended Standards
- Decitabine Impurity 46 (CAS CATO-C4X-113746)
- Istradefylline Impurity 3 (CAS 155272-04-1)
- Cefotiam Impurity 1 (CAS 775233-43-7)
- Istradefylline Impurity 24 (CAS 155270-98-7)
- Pyridoxine impurity 93 (CAS 524-07-2)
- Melphalan Impurity 24 (CAS CATO-C4X-198824)
- Rebamipide Impurity 66 (CAS CATO-C4X-152366)
- 7-Chloro-2-(4-methoxybenzyl)-3-methyl-5-propylbenzofuran-4-ol (CAS 102612-16-8)
- (2-(1-Benzylpiperidin-2-yl)cyclopropyl)methanamine (CAS 1824016-51-4)
- Methyl 2-bromo-5-(trifluoromethyl)nicotinate (CAS 888738-49-6)
- 2-Methyl-3-(3-methylpyridin-2-yl)quinazolin-4(3H)-one (CAS 3214-64-0)
- 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic Acid Methyl Ester (CAS 1035912-44-7)
- 1-(4-(Dimethylamino)phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde (CAS 32570-93-7)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
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