7-(Trifluoromethyl)spiro[chromane-4,4'-piperidine] CAS 2379928-22-8
| CAS No. | 2379928-22-8 |
| Molecular Formula | C14H16F3NO |
| Molecular Weight | 271.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 7-(Trifluoromethyl)spiro[chromane-4,4'-piperidine] is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 7-(Trifluoromethyl)spiro[chromane-4,4'-piperidine] (CAS 2379928-22-8), a certified reference material (molecular formula C14H16F3NO, MW 271.28 g/mol) for analytical method development and quality control.
The molecular framework of 7-(Trifluoromethyl)spiro[chromane-4,4'-piperidine] (C14H16F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 7-(Trifluoromethyl)spiro[chromane-4,4'-piperidine] meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H16F3NO |
| Molecular Weight | 271.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 3-Benzyl-6-(trifluoromethyl)-3-azabicyclo[3.1.1]Heptan-6-ol (CAS 1240525-80-7)
- 1-Methyl-3-(4-(trifluoromethyl)benzyl)piperidin-4-one (CAS 1956386-02-9)
- 6'-(Trifluoromethyl)-2'H-spiro[azepane-4,3'-benzofuran] (CAS 2351201-14-2)
- 3-(4-(trifluoromethyl)phenyl)-8-azabicyclo[3.2.1]octan-3-ol (CAS CATO-C3D-262423)
- 2-(5-(4-(Trifluoromethyl)phenyl)furan-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 730958-61-9)
- 1-[2-(2-Trifluoromethyl-phenyl)-thiazol-4-yl]-ethanone (CAS 1469150-14-8)
- 1-[2-(3-Trifluoromethyl-phenyl)-thiazol-4-yl]-ethanone (CAS 1487901-79-0)
- 4-((4-(Trifluoromethyl)pyridin-2-yl)thio)pyridin-3-amine (CAS 1505372-23-5)
Recommended Standards
- N-(4-Cyclohexylphenyl)-2,2,2-trifluoroacetamide (CAS 340034-55-1)
- 5-(Cyclohex-1-en-1-yl)-5-phenylimidazolidine-2,4-dione (CAS 92579-78-7)
- 2H-Benzo[c]-1,2,3-triazolo[4,5-a]phenazine (CAS 216-25-1)
- 2-(4-Acetylbenzenesulfonamido)propanoic acid (CAS 1008958-60-8)
- 4-chloro-2-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 1379340-05-2)
- tert-Butyl 4-chloro-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate (CAS 2089314-78-1)
- tert-Butyl N-[(3S,4R)-4-hydroxypiperidin-3-yl]carbamate (CAS 1549812-73-8)
- Potassium trifluoro(4-(4-methylpiperazin-1-yl)phenyl)borate (CAS 1691248-19-7)
- Methyl 4,5-Dichloroindole-2-carboxylate (CAS 952958-53-1)
- 2-Amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide (CAS 40106-15-8)
- 1H-Indole-3,4-dicarbaldehyde (CAS 1174005-75-4)
- Tert-butyl 7-[1-(cyclopropylmethyl)-2-methoxy-2-oxo-ethyl]-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate (CAS 2755949-41-6)
- 4-Bromo-3,5-difluorobenzyl chloride (CAS 1805524-18-8)
- Myristoyl Pentapeptide -4 acetate (CAS 959610-30-1(free base))
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