Nintedanib Impurity 69 CAS 2380229-45-6
| CAS No. | 2380229-45-6 |
| Molecular Formula | C33H35N5O5 |
| Molecular Weight | 581.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nintedanib Impurity 69 (CAS 2380229-45-6, C33H35N5O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nintedanib Impurity 69 (C33H35N5O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 19.0, corresponding to approximately 19 ring(s) or double-bond equivalent(s). With a molecular weight of 581.66 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 69 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H35N5O5 |
| Molecular Weight | 581.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 5 |
Related Nintedanib Standards
- Nintedanib Impurity 30 (CAS CATO-C4X-181430)
- Nintedanib impurity 86 (CAS CATO-C4X-181486)
- Nintedanib Impurity 20 (CAS 2734676-68-5)
- Nintedanib Impurity 76 (CAS CATO-C4X-181476)
- Nintedanib impurity 78 (CAS CATO-C4X-181478)
- Nintedanib Impurity 74 (CAS CATO-C4X-181474)
- Nintedanib Impurity 94 (CAS CATO-C4X-181494)
- Nintedanib Impurity 171 (CAS CATO-C4X-1814171)
Recommended Standards
- Amoxicillin Impurity 86 (CAS CATO-C4X-114886)
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- 4-(Trifluoromethyl)tetrahydro-2H-thiopyran-4-ol (CAS 1247519-72-7)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
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