Cabozantinib Impurity 15 CAS 849217-77-2
| CAS No. | 849217-77-2 |
| Molecular Formula | C22H20N2O6 |
| Molecular Weight | 408.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cabozantinib Impurity 15.
As a process- or degradation-related impurity, Cabozantinib Impurity 15 (CAS 849217-77-2, C22H20N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cabozantinib Impurity 15 (C22H20N2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H20N2O6 |
| Molecular Weight | 408.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 14 (CAS CATO-C4X-201814)
- Cabozantinib Impurity 18 (CAS CATO-C4X-201818)
- Cabozantinib Impurity N3 (CAS 651054-52-3)
- Cabozantinib Impurity 50 (CAS CATO-C4X-201850)
- Cabozantinib Impurity 13 (CAS 849221-94-9)
- Cabozantinib Impurity 45 (CAS CATO-C4X-201845)
- Cabozantinib Impurity 23 (CAS CATO-C4X-201823)
- Cabozantinib Impurity 2 (CAS 190728-24-6)
Recommended Standards
- Irinotecan Impurity 64 (CAS CATO-C4X-166764)
- Roxadustat Impurity 88 (CAS CATO-C4X-221388)
- Gefitinib Impurity 82 (CAS CATO-C4X-111782)
- Salcaprozate Impurity 3 (CAS CATO-C4X-25073)
- Clopidogrel Impurity 118 (CAS CATO-C4X-1029118)
- Dorzolamide EP Impurity D (CAS 154154-90-2)
- Rapamycin Impurity 12 (CAS 150821-39-9)
- 1-Benzyl-5-(hexyloxy)pyrrolidin-2-one (CAS 119984-48-4)
- Fluazifop-Methyl (CAS 69335-90-6)
- Methyl 4-methyl-5-[4-(propan-2-yl)phenyl]thiophene-2-carboxylate (CAS 1855889-97-2)
- 2-(4-((Ethylthio)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1256359-06-4)
- 4-Chloro-2-(thiophen-2-yl)benzofuro[3,2-d]pyrimidine (CAS 1706442-99-0)
- 6-(Methoxyamino)-5-methylpyrimidin-2(1H)-one (CAS 68141-18-4)
- Peptide 434 (CAS CATO-CPTD788434)
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