Formoterol impurity 131 CAS 2386293-34-9（free base）
| CAS No. | 2386293-34-9（free base） |
| Molecular Formula | C18H23NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Formoterol impurity 131 (CAS 2386293-34-9（free base）, C18H23NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Formoterol impurity 131 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 305.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Formoterol impurity 131 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23NO HCl |
| Molecular Weight | 305.85 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Formoterol Standards
- Formoterol Impurity 69 (CAS 100865-09-6)
- Formoterol-d6(Mixture of Diastereomers) (CAS 1020719-45-2)
- Formoterol Impurity 22 HCl (CAS 1049695-95-5)
- Formoterol Impurity 72 (CAS 108971-53-5)
- Formoterol EP Impurity B (CAS 1224588-66-2)
- Formoterol Impurity 19 (CAS 126002-14-0)
- Formoterol Impurity 28 (CAS 126587-86-8)
- Formoterol (Mixture of Diastereomers) (CAS 128954-45-0)
Recommended Standards
- Azithromycin Impurity 36 (CAS 57794-18-0)
- Ketoprofen EP Impurity A (CAS 66067-44-5)
- Dobutamine Impurity 20 HCl (CAS 140165-60-2 (free base))
- Ethyl 2-(4-amino-3-(dimethylphosphoryl)phenyl)acetate (CAS 1887181-12-5)
- 4-(2-Aminoethyl)-1λ4-thiomorpholin-1-one dihydrochloride (CAS 1354951-49-7)
- 4-Chloro-3-(2-chloroethyl)-2-methyl-8-(trifluoromethyl)quinoline (CAS 685108-61-6)
- 1-Bromo-4-(2-bromopropyl)benzene (CAS 1310280-63-7)
- (S)-3-((2-Amino-8-fluoroquinazolin-4-yl)amino)hexan-1-ol (CAS 1413944-59-8)
- 3-N-Acetyl-amifampridine (CAS 750570-35-5)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
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