Ketoprofen EP Impurity A CAS 66067-44-5
| CAS No. | 66067-44-5 |
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ketoprofen EP Impurity A.
Ketoprofen EP Impurity A (CAS 66067-44-5) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12O2 and a molecular weight of 224.25 g/mol.
The molecular framework of Ketoprofen EP Impurity A (C15H12O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
Related Ketoprofen Standards
- Ketoprofen Impurity 53 (CAS 1420774-68-0)
- Ketoprofen Impurity 114 (CAS 32388-73-1)
- Ketoprofen Impurity 82 (CAS CATO-C4X-147182)
- Ketoprofen Impurity 85 (CAS CATO-C4X-147185)
- Ketoprofen impurity 75 (CAS 319482-67-2)
- Ketoprofen EP Impurity I (CAS 21288-34-6)
- Ketoprofen Impurity 108 (CAS CATO-C4X-1471108)
- Ketoprofen Impurity 109 (CAS CATO-C4X-1471109)
Recommended Standards
- Propafenone EP Impurity H (CAS 487-26-3)
- Loxoprofen impurity 120 (CAS CATO-C4X-1488120)
- Propafenone EP Impurity H(R-isomer) (CAS 27439-12-9)
- Loxoprofen impurity 121 (CAS CATO-C4X-1488121)
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Bisoprolol Impurity 113 (CAS CATO-C4X-1247113)
- Atracurium impurity 102 (CAS 83518-38-1)
- 2-(6-fluoro-5-methyl-1H-indol-3-yl)ethan-1-amine hydrochloride (CAS 2060062-32-8)
- Methyl 4-(4-(2,6-dimethylphenyl)piperazin-1-yl)-3-nitrobenzoate (CAS 478246-61-6)
- 3,5-dimethyl-1-(3,3,3-trifluoropropyl)-1H-pyrazole-4-sulfonyl chloride (CAS 1339091-50-7)
- 2-Amino-1-cyclopentyl-4,5-dimethyl-1h-pyrrole-3-carbonitrile (CAS 103026-11-5)
- 6-(Methylcarbamoyl)pyridine-3-boronic Acid Pincol Ester (CAS 945863-21-8)
- N-(5-(2-(5-Nitrofuran-2-yl)vinyl)-1,3,4-oxadiazol-2-yl)acetamide (CAS 24167-19-9)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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