Rebamipide Impurity 57 CAS 23976-45-6
| CAS No. | 23976-45-6 |
| Molecular Formula | C10H9Br2NO2 |
| Molecular Weight | 334.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rebamipide Impurity 57.
Rebamipide Impurity 57 (CAS 23976-45-6) is a certified pharmaceutical impurity reference standard with the molecular formula C10H9Br2NO2 and a molecular weight of 334.99 g/mol.
The molecular framework of Rebamipide Impurity 57 (C10H9Br2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9Br2NO2 |
| Molecular Weight | 334.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Rebamipide Standards
- Rebamipide Impurity 50 (CAS CATO-C4X-152350)
- Rebamipide Impurity 67 (CAS CATO-C4X-152367)
- Rebamipide Impurity 54 (CAS CATO-C4X-152354)
- Rebamipide impurity 24 (CAS CATO-C4X-152324)
- Rebamipide Impurity 33 (CAS CATO-C4X-152333)
- Rebamipide Impurity 4 (CAS 100342-53-8)
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Recommended Standards
- N-(2-acetyl-4,6-dibromophenyl)acetamide (CAS 88092-70-0)
- 2',4,4',6'-Tetrachloro-[1,1'-biphenyl]-3-carboxamide (CAS 1361542-39-3)
- 5-Fluoro-2-iodo-1-nitro-3-(trifluoromethyl)benzene (CAS 1980034-09-0)
- 3-Chloro-N-(2,4,6-trichlorophenyl)benzamide (CAS 91822-20-7)
- Clopidogrel Impurity 26 (CAS CATO-C4X-102926)
- Tofacitinib Impurity 168 (CAS CATO-C4X-1079168)
- Nicorandil Impurity 12 (CAS 83440-03-3)
- 2-Methyl-2H-indazole-4-sulfonyl chloride (CAS 1363381-73-0)
- n,n-Dimethyl-3-(piperazin-1-yl)propanamide (CAS 89009-68-7)
- Ethyl 2-((1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl)thio)propanoate (CAS 899988-35-3)
- Dutaverine Impurity 33 HCl (CAS CATO-C4X-243533)
- (5-Bromofuran-2-yl)(3-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methanone (CAS 1327575-52-9)
- Spiperone-d5 (CAS 1215666-36-6)
- Experimental Allergic Encephalitogenic Peptide (CAS 29705-92-8)
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