Tofacitinib Impurity 168 CAS CATO-C4X-1079168
| CAS No. | CATO-C4X-1079168 |
| Molecular Formula | C15H20ClN5O |
| Molecular Weight | 321.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tofacitinib Impurity 168 (C15H20ClN5O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Tofacitinib Impurity 168 (CAS CATO-C4X-1079168), a pharmacopoeial impurity reference standard (molecular formula C15H20ClN5O, MW 321.81 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 168 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H20ClN5O |
| Molecular Weight | 321.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 87 (CAS 4124-41-8)
- Tofacitinib Impurity 113 (CAS CATO-C4X-1079113)
- Tofacitinib Impurity 48 (CAS CATO-C4X-107948)
- Tofacitinib Impurity 232 (CAS CATO-C4X-1079232)
- Tofacitinib Impurity 119 (CAS 2407039-29-4)
- Tofacitinib Impurity 139 (CAS CATO-C4X-1079139)
- Tofacitinib Impurity 159 (CAS 1640971-51-2)
- Tofacitinib Impurity 171 (CAS CATO-C4X-1079171)
Recommended Standards
- Copper(II) Acetoacetate (CAS 14284-06-1)
- 1-((4-(2-Chloroethyl)phenyl)sulfonyl)indoline (CAS 1018537-56-8)
- Montelukast Impurity 42 (CAS 149968-10-5)
- 3-Chloro-4-fluoro-N-[2-(isopentyloxy)benzyl]-aniline (CAS 1040685-54-8)
- Sulfasalazine EP Impurity E (CAS 1391062-34-2)
- Bortezomib Impurity N32 (CAS 84110-34-9)
- Furosemide Impurity 15 (CAS CATO-C4X-140215)
- Ethyl 3-(4-Hydroxyphenyl)-5-methylisoxazole-4-carboxylate (CAS 1071788-87-8)
- 6-Chloro-2,2-dimethyl-2,3-dihydro-1H-inden-1-one (CAS 13099-73-5)
- 2-Chloro-6,7-dimethyl-3,4-dihydroquinazolin-4-one (CAS 20270-03-5)
- (SP-4-1)-Bis(triphenylphosphine)palladium(II) dichloride (CAS 28966-81-6)
- N-(4-Iodophenyl)-4-methoxybenzenesulfonamide (CAS 314054-03-0)
- 2-Fluorophenyl 5-chloro-2-(methylthio)pyrimidine-4-carboxylate (CAS 879947-99-6)
- Nonapeptide-1 (CAS 158563-45-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com