4-Hydroxy-5,7-bis(trifluoromethyl)quinoline-3-carboxylic acid CAS 240408-95-1
| CAS No. | 240408-95-1 |
| Molecular Formula | C12H5F6NO3 |
| Molecular Weight | 325.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Hydroxy-5,7-bis(trifluoromethyl)quinoline-3-carboxylic acid (CAS 240408-95-1), molecular formula C12H5F6NO3 and molecular weight 325.16 g/mol, is a CATO reference standard with documented purity and traceability.
4-Hydroxy-5,7-bis(trifluoromethyl)quinoline-3-carboxylic acid (C12H5F6NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-Hydroxy-5,7-bis(trifluoromethyl)quinoline-3-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H5F6NO3 |
| Molecular Weight | 325.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 4-Hydroxy-2,7-bis(trifluoromethyl)quinoline-3-carboxylic acid (CAS 75999-57-4)
- 4-Hydroxy-2,8-bis(trifluoromethyl)quinoline-3-carboxylic acid (CAS 75999-54-1)
- 1-Hydroxy-4-(4-nitrophenoxy)-2-naphthoic acid (CAS 21894-06-4)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(2-methylpiperidin-1-yl)thiophen-2-yl)boronate (CAS 2223009-25-2)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(3-methylpiperidin-1-yl)thiophen-2-yl)boronate (CAS 2223003-62-9)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(4-methylpiperidin-1-yl)thiophen-2-yl)boronate (CAS 2223031-88-5)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(2-methylpiperidin-1-yl)thiophen-2-yl)boronate (CAS 2223003-34-5)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(3-methylpiperidin-1-yl)thiophen-2-yl)boronate (CAS 2223002-76-2)
Recommended Standards
- 5-(Trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)oxazole-4-carboxylic acid (CAS 886497-47-8)
- 5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carboxylic acid (CAS 850893-02-6)
- 4-Bromo-5-methoxy-2-(4-methoxybenzyl)pyridazin-3(2H)-one (CAS 2381044-54-6)
- 5-Bromo-1'H,3H-[2,3'-biindol]-3-one (CAS 92967-81-2)
- N-[(Pyridin-2-yl)methyl]-3-[5-(trifluoromethyl)pyridin-2-yl]benzamide (CAS 1092345-85-1)
- 2-Thiazol-2-yl-phenylamine (CAS 923946-90-1)
- 9(10)-Dehydronandrolone (CAS 6218-29-7)
- 7-(1,3-Dioxaindan-5-yl)-1-methyl-2,4-dioxo-1h,2h,3h,4h-pyrido[2,3-d]pyrimidine-5-carboxylic acid (CAS 879303-83-0)
- Rimegepant Impurity 59 (CAS 1190363-47-3)
- Asciminib Impurity 2 (CAS 1492954-67-2)
- 3-(3-Phenyl-1,2,4-oxadiazol-5-yl)-1,2-dihydropyridin-2-one (CAS 950265-32-4)
- (1R,2S)-2-Amino-cyclohex-3-enecarboxylic acid hydrochloride (CAS 131783-54-5)
- 2-[[2-[(4-Fluorophenyl)amino]-2-oxoethyl]amino]-benzoic acid (CAS 1394021-66-9)
- Tirzepatide Impurity 20 (CAS CATO-C4X-324020)
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