Rimegepant Impurity 59 CAS 1190363-47-3
| CAS No. | 1190363-47-3 |
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Rimegepant Impurity 59 (C25H35F2NO2Si) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Rimegepant Impurity 59 (CAS 1190363-47-3), a pharmacopoeial impurity reference standard (molecular formula C25H35F2NO2Si, MW 447.63 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H35F2NO2Si |
| Molecular Weight | 447.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Rimegepant Standards
- Rimegepant Impurity 145 (CAS CATO-C4X-2487145)
- Rimegepant Impurity 17 (CAS 1190363-50-8)
- Rimegepant Impurity 18 (CAS 1289023-95-5)
- Rimegepant Impurity 15 (CAS 1289024-42-5)
- Rimegepant Impurity 116 (CAS CATO-C4X-2487116)
- Rimegepant Impurity 125 (CAS CATO-C4X-2487125)
- Rimegepant Impurity 159 (CAS CATO-C4X-2487159)
- Rimegepant Impurity 160 (CAS CATO-C4X-2487160)
Recommended Standards
- 1,3,5-Tris((pyridin-4-ylthio)methyl)benzene (CAS 862014-52-6)
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- 3,3-Dibutyl-8-hydroxy-7-(methylthio)-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepine 1,1-dioxide (CAS 439088-16-1)
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- Fasudil Impurity 44 (CAS 84468-22-4)
- Upadacitinib Impurity 222 (CAS CATO-C4X-2405222)
- Acotiamide Impurity 7 (CAS 185105-13-9)
- N-(Piperidin-4-ylmethyl)-1-(pyrazin-2-yl)ethanamine hydrochloride (CAS 1289385-75-6)
- N’-hydroxy-2-phenoxypyridine-3-carboximidamide (CAS 1016752-79-6)
- 7-Methoxybenzothiazole-2-carboxylic acid (CAS 1188162-80-2)
- Metformin-d6 Hydrochloride (CAS 1185166-01-1)
- (1R,5S,9r)-7-benzyl-3-thia-7-azabicyclo[3.3.1]nonane-9-carbonitrile (CAS 1691197-40-6)
- (2S,3S)-1,4-dimethoxybutane-2,3-diol (CAS 50622-10-1)
- Retatrutide (CAS 2381089-83-2)
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