Nintedanib Impurity 8 CAS 2410649-54-4
| CAS No. | 2410649-54-4 |
| Molecular Formula | C22H26N6O6 |
| Molecular Weight | 470.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nintedanib Impurity 8 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Nintedanib Impurity 8 (CAS 2410649-54-4) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26N6O6 and a molecular weight of 470.48 g/mol.
Based on its molecular formula C22H26N6O6, Nintedanib Impurity 8 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 470.48 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26N6O6 |
| Molecular Weight | 470.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 6 |
Related Nintedanib Standards
- Nintedanib impurity 182 (CAS CATO-C4X-1814182)
- Nintedanib Impurity N5 (CAS 262366-32-5)
- Nintedanib Impurity 177 (CAS CATO-C4X-1814177)
- Nintedanib Impurity 172 (CAS CATO-C4X-1814172)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
- Nintedanib Impurity 107 (CAS CATO-C4X-1814107)
- Nintedanib Impurity 104 (CAS CATO-C4X-1814104)
- Nintedanib Impurity 143 (CAS CATO-C4X-1814143)
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- 1,3-Dimethyl-5-{[(piperidin-4-ylmethyl)amino]methylene}pyrimidine-2,4,6(1H,3H,5H)-trione (CAS 362495-00-9)
- 6-Iodo-4-methylnicotinic acid (CAS 1355208-03-5)
- TERT-BUTYL 3-CARBAMOYLINDOLINE-1-CARBOXYLATE (CAS 1824025-90-2)
- N-Benzyl 5-borono-2-methoxybenzenesulfonamide (CAS 874219-51-9)
- 4-((4-Chlorobenzyl)oxy)benzoic acid (CAS 62290-40-8)
- FLAG Epitope Peptide (CAS 98849-88-8)
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