Nintedanib Impurity 143 CAS CATO-C4X-1814143
| CAS No. | CATO-C4X-1814143 |
| Molecular Formula | C20H15Cl2NO5 |
| Molecular Weight | 420.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C20H15Cl2NO5, Nintedanib Impurity 143 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 420.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Nintedanib Impurity 143 (CAS CATO-C4X-1814143), a pharmacopoeial impurity reference standard (molecular formula C20H15Cl2NO5, MW 420.24 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H15Cl2NO5 |
| Molecular Weight | 420.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 144 (CAS CATO-C4X-1814144)
- Nintedanib Impurity 145 (CAS CATO-C4X-1814145)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity 107 (CAS CATO-C4X-1814107)
- Nintedanib Impurity 1 (CAS 2410284-89-6)
- Nintedanib Impurity 28 (CAS CATO-C4X-181428)
- Nintedanib Impurity N4 (CAS 1987887-92-2)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
Recommended Standards
- Amiodarone Hydrochloride EP Impurity F (CAS 147030-50-0)
- 2-Amino-4-(3-iodophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (CAS 337496-56-7)
- Propanedioic acid, 2-(6-iodo-3-pyridazinyl)-, 1,3-bis(1,1-dimethylethyl) ester (CAS 1853166-10-5)
- 1-(2,4-Dichlorophenyl)-4-methyl-5-(4-nitrophenyl)-1H-pyrazole-3-carboxylic Acid Ethyl Ester (CAS 221385-24-6)
- Ceftazidime Impurity 31 (CAS CATO-C4X-121231)
- Ertapenem Impurity 5 (CAS CATO-C4X-16335)
- Bosutinib Impurity 5 (CAS 1460227-29-5)
- 1-(2,6-Dichlorophenyl)cyclobutanamine Hydrochloride (CAS 1803598-02-8)
- 5-Amino-6-bromopyrimidin-4(1H)-one (CAS 1369139-49-0)
- 4-(4-Fluorophenyl)but-3-yn-2-amine (CAS 1602914-48-6)
- (2-(Hydroxymethyl)phenyl)diphenylphosphine oxide (CAS 68718-89-8)
- 1024769-57-0 Aza(3-(4-chloro-3-methylphenyl)-7,7-dimethyl(6,7,8-trihydrocinnolin-5-ylidene))ethoxymethane MFCD00245682 (CAS 1024769-57-0)
- 4-Bromo-2-methoxy-5-nitroaniline (CAS 1421371-97-2)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
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