5-Oxo-2-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide CAS 241127-08-2
| CAS No. | 241127-08-2 |
| Molecular Formula | C21H10F6N2O3 |
| Molecular Weight | 452.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Oxo-2-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide.
5-Oxo-2-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 241127-08-2), molecular formula C21H10F6N2O3 and molecular weight 452.31 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 5-Oxo-2-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 452.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Oxo-2-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H10F6N2O3 |
| Molecular Weight | 452.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Oxo Standards
- 2,4-Bis(trifluoromethyl)-7-[(E)-2-{[3-(trifluoromethyl)phenyl]methylidene}hydrazin-1-yl]-1,8-naphthyridine (CAS 338962-17-7)
- 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(3,4-dimethoxyphenethyl)thiourea (CAS 883041-21-2)
- 1-{[3,5-Bis(trifluoromethyl)phenyl]methyl}-3,5-dibromo-1h-1,2,4-triazole (CAS 1240568-76-6)
- 1-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4-(4-methoxyphenyl)-1H-pyrazol-5-amine (CAS 321522-21-8)
- 4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}-1-{[3-(trifluoromethyl)phenyl]methyl}piperidine (CAS 1025724-60-0)
- 1-Acetyl-5-[[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]sulfonyl]indoline (CAS 901260-40-0)
- 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid (CAS 1076197-34-6)
- 3,3''-Bis(trifluoromethyl)-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid (CAS 2308530-30-3)
Recommended Standards
- 2-Iodo-N-(3-(2-methoxyethyl)-6-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide (CAS 864975-06-4)
- 9-(4-fluorobenzylidene)-2,4,5,7-tetranitro-9H-fluorene (CAS 253605-81-1)
- 1-[(2,4-Dichlorophenyl)methyl]-2-oxo-N-(4-sulfamoylphenyl)-1,2-dihydropyridine-3-carboxamide (CAS 320419-68-9)
- N-(3-(2-Ethoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-2-iodobenzamide (CAS 865162-48-7)
- 4-Amino-3-Fluorophenol (CAS 399-95-1)
- 5'-Methoxyspiro[cyclopropane-1,3'-indoline] (CAS 1461706-07-9)
- D-Carglumic Acid (1096564) (CAS 26117-15-7)
- Crisaborole Impurity 9 (CAS 906673-30-1)
- 2-(4-Chloro-2,3-dimethylphenyl)propan-2-ol (CAS 2586126-08-9)
- 4-N-Nonylphenol（mixture of isomers） (CAS 104-40-5)
- tert-Butyl 4-(ethoxycarbonylamino)piperidine-1-carboxylate (CAS 1233955-10-6)
- 2-(1h-Pyrazol-1-yl)imidazo[1,2-a]pyridine-3-carbaldehyde (CAS 1153319-43-7)
- [(2-Isopropylpyrimidin-4-yl)methyl]aminedihydrochloride (CAS 1332528-73-0)
- Tau Peptide (379-408) trifluoroacetate salt (CAS 1246357-53-8)
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