Sitafloxacin impurity 77 CAS 2412444-06-3
| CAS No. | 2412444-06-3 |
| Molecular Formula | C18H18ClF2N3O |
| Molecular Weight | 365.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 365.80 g/mol gives Sitafloxacin impurity 77 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Sitafloxacin impurity 77 (CAS 2412444-06-3) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18ClF2N3O and a molecular weight of 365.80 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Sitafloxacin impurity 77 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 365.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18ClF2N3O |
| Molecular Weight | 365.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Sitafloxacin Standards
- Sitafloxacin Impurity 27 (CAS CATO-C4X-115527)
- Sitafloxacin impurity 75 (CAS CATO-C4X-115575)
- Sitafloxacin impurity 89 (CAS CATO-C4X-115589)
- Sitafloxacin Dechloro Impurity (CAS CATO-C4X-115524)
- Sitafloxacin Impurity 29 (CAS CATO-C4X-115529)
- Sitafloxacin Impurity N13 (CAS 127199-25-1)
- Sitafloxacin Impurity 1 (CAS CATO-C4X-11551)
- Sitafloxacin Impurity 69 (CAS CATO-C4X-115569)
Recommended Standards
- Methyl (S)-4-(2-Chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidine-5-carboxylate (CAS 1236208-59-5)
- N-(3-chloro-5-fluorophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (CAS 882082-07-7)
- Pelabresib (CPI-0610) (CAS 1380087-89-7)
- N-(3-chloro-4-fluorophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)acetamide (CAS 329079-97-2)
- Celecoxib Impurity 12 (CAS 1061214-09-2)
- Trazodone Impurity 109 (CAS CATO-C4X-1772109)
- Atorvastatin Impurity 77 (CAS 2299304-89-3)
- Maytansinoid DM1 (CAS 139504-50-0)
- (S)-2-(3-Bromophenyl)piperidine (CAS 1228557-44-5)
- N-[(E)-(5-Bromo-2-ethoxyphenyl)methylidene]isonicotinohydrazide (CAS 338393-52-5)
- O-(3-Buten-2-yl)hydroxylamine Hydrochloride (CAS 71350-16-8)
- 3-Bromo-4-(ethylamino)-5-nitrobenzonitrile (CAS 1420800-37-8)
- 2-(3,3-Dimethylazetidin-1-yl)acetic acid (CAS 1508708-79-9)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
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