Sunitinib Impurity 29 CAS 2417674-16-7
| CAS No. | 2417674-16-7 |
| Molecular Formula | C22H27FN4O2 |
| Molecular Weight | 398.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sunitinib Impurity 29.
As a process- or degradation-related impurity, Sunitinib Impurity 29 (CAS 2417674-16-7, C22H27FN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sunitinib Impurity 29 (C22H27FN4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sunitinib Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H27FN4O2 |
| Molecular Weight | 398.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sunitinib Standards
- Sunitinib Impurity 28 (CAS CATO-C4X-133328)
- Sunitinib Impurity 30 (CAS CATO-C4X-133330)
- Sunitinib Impurity 31 (CAS 342641-94-5)
- Sunitinib (CAS 557795-19-4)
- (E)-Sunitinib (CAS 1691223-83-2)
- Sunitinib impurity 69 (CAS CATO-C4X-133369)
- Sunitinib-d4 (CAS 1126721-79-6)
- Sunitinib Impurity 65 (CAS CATO-C4X-133365)
Recommended Standards
- Atorvastatin Impurity 124 (CAS 666714-64-3)
- Tris(2-ethylhexyl) borate (CAS 2467-13-2)
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- Trimethoprim EP Impurity F (CAS 16285-82-8)
- Gentamicin Impurity 13 (CAS 49751-51-1)
- Esmolol Impurity 97 (CAS CATO-C4X-189197)
- 5-(Aminomethyl)-1-cyclopropylpyrimidine-2,4(1H,3H)-dione hydrochloride (CAS 2034154-05-5)
- 4-[2-(1-Pyrrolidinyl)ethoxy]benzophenone (CAS 179018-53-2)
- Phenylmethyl N-(2-aminoethyl)-N-methylcarbamate (CAS 19023-94-0)
- 3-Fluorophenoxyacetonitrile (CAS 135290-20-9)
- 3-Bromo-3'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1443305-31-4)
- N-methyl-2-(3-methyl-1,2,4-oxadiazol-5-yl)cyclopentan-1-amine (CAS 1340457-68-2)
- Calcitonin C-Terminal Flanking Peptide (human) XTFA (CAS 85916-47-8（free base）)
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