Sunitinib Impurity 65 CAS CATO-C4X-133365
| CAS No. | CATO-C4X-133365 |
| Molecular Formula | C23H18F2N4O |
| Molecular Weight | 404.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Sunitinib Impurity 65 (CAS CATO-C4X-133365, C23H18F2N4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sunitinib Impurity 65 (C23H18F2N4O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Sunitinib Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H18F2N4O |
| Molecular Weight | 404.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sunitinib Standards
Recommended Standards
- Linezolid Impurity 91 (CAS CATO-C4X-107391)
- Nimodipine Impurity 25 (CAS 82219-47-4)
- Pinostilbenoside (CAS 58762-96-2)
- Nimodipine Impurity 33 (CAS 39562-75-9)
- Bedaquiline impurity 40 (CAS 848694-09-7)
- Parecoxib Impurity 51 (CAS 2304623-35-4)
- Acotiamide Impurity 28 (CAS 185104-11-4)
- (4-Isopropylphenyl)(p-tolyl)iodonium chloride (CAS 178233-70-0)
- 3,5-Diiodothiophene-2-carboxylic acid (CAS 1389313-38-5)
- 2,2,2-Trifluoro-1-(4-heptylphenyl)ethan-1-one (CAS 1256482-54-8)
- n1-Cyclobutylbenzene-1,2-diamine (CAS 1190630-91-1)
- 1-(Pyridin-3-ylmethyl)piperidin-3-amine trihydrochloride (CAS 1158689-23-6)
- 898776-09-5 Ethyl 8-cyclopentyl-8-oxooctanoate DTXSID60645653 (CAS 898776-09-5)
- D-Pro38-Tirzepatide (CAS CATO-CPTD788901)
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