Apalutamide Impurity 12 CAS 2422147-84-8
| CAS No. | 2422147-84-8 |
| Molecular Formula | C8H5F3N4S |
| Molecular Weight | 246.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C8H5F3N4S, Apalutamide Impurity 12 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 246.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Apalutamide Impurity 12 (CAS 2422147-84-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H5F3N4S and a molecular weight of 246.21 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5F3N4S |
| Molecular Weight | 246.21 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Apalutamide Standards
- Apalutamide Impurity 66 (CAS CATO-C4X-274966)
- Apalutamide Impurity 15 (CAS 915087-26-2)
- Apalutamide Impurity 34 (CAS CATO-C4X-274934)
- Apalutamide impurity 88 (CAS 1367708-38-0)
- Apalutamide Impurity 38 (CAS CATO-C4X-274938)
- Apalutamide Impurity 24 (CAS CATO-C4X-274924)
- Apalutamide Impurity 71 (CAS CATO-C4X-274971)
- Apalutamide Impurity 62 (CAS CATO-C4X-274962)
Recommended Standards
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- Enzalutamide Impurity 36 (CAS CATO-C4X-101636)
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- 2-Benzoyl-5-methylcyclohexane-1,3-dione (CAS 372963-64-9)
- Methyl 5-acetyl-1,2,4-trimethyl-1H-pyrrole-3-carboxylate (CAS 90433-82-2)
- 5-Chloro-3-(4-nitrophenyl)-1,2,4-thiadiazole (CAS 88541-07-5)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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