itagliptin Impurity 120 CAS 2428591-91-5
| CAS No. | 2428591-91-5 |
| Molecular Formula | C9H5F3O4 |
| Molecular Weight | 234.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of itagliptin Impurity 120 (C9H5F3O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, itagliptin Impurity 120 (CAS 2428591-91-5, C9H5F3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), itagliptin Impurity 120 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5F3O4 |
| Molecular Weight | 234.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
Recommended Standards
- 4-HYDROXY-7-BROMOQUINOLINE 7-BROMO-4-HYDROXYQUINOLINE 7-BROMOQUINOLIN-4-OL 82121-06-0 ABBYPHARMA AP-13-10739 BC004109 BUTTPARK 100\01-52 (CAS 82121-06-0)
- 5-bromo-1-ethyl-1H-pyrazolo[3,4-b]pyridine (CAS 1016721-67-7)
- 64965-47-5 3-Bromo-4-hydroxyquinoline MFCD00234483 (CAS 64965-47-5)
- 5-bromo-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine (CAS 1016842-99-1)
- Vancomycin EP Impurity G (CAS CATO-C4X-17758)
- Nimesulide EP Impurity F (CAS 51765-72-1)
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- 2,6-Dichloro-3-(4-methylphenyl)propiophenone (CAS 898769-46-5)
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- 2-Bromo-6-hydroxy-5-methoxy-3-nitrobenzaldehyde (CAS 205652-99-9)
- Ethyl 3,6-dimethyl-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (CAS 51618-12-3)
- 9,9-Dimethyl-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline (CAS 1267409-40-4)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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