Nimesulide EP Impurity F CAS 51765-72-1
| CAS No. | 51765-72-1 |
| Molecular Formula | C14H14N2O7S2 |
| Molecular Weight | 386.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nimesulide EP Impurity F.
Nimesulide EP Impurity F (CAS 51765-72-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H14N2O7S2 and a molecular weight of 386.40 g/mol.
Structurally, Nimesulide EP Impurity F (C14H14N2O7S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 386.40 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14N2O7S2 |
| Molecular Weight | 386.40 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Nimesulide Standards
- Nimesulide EP Impurity A (CAS 51765-56-1)
- Nimesulide EP Impurity E (CAS 905858-63-1)
- Nimesulide (CAS 51803-78-2)
- Nimesulide Impurity N1 (CAS 19881-18-6)
- Nimesulide EP Impurity B (CAS 51765-51-6)
- Nimesulide Impurity 2 (CAS 38880-53-4)
- Nimesulide EP Impurity G (CAS 70995-08-3)
- Nimesulide EP Impurity D (CAS 5422-92-4)
Recommended Standards
- (S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoic acid 7720-37-8 Ac-Tyr-Tyr-OH (CAS 7720-37-8)
- Fenofibrate Impurity 9 (CAS CATO-C4X-16439)
- (S)-2,4-bis(benzyloxycarbonylamino)butanoic acid 55478-23-4 N-alpha,gamma-Bis-Z-L-2,4-diaminobutyric acid (CAS 55478-23-4)
- Nisoldipine USP Related Compound D (CAS 103026-83-1)
- Dronedarone Impurity 31 (CAS 2540665-66-3)
- Ceftriaxone Impurity 23 (CAS CATO-C4X-116323)
- Doxycycline EP Impurity D (CAS 97583-08-9)
- N-Methyl-1-(4-(pyridin-3-yl)phenyl)methanamine Hydrochloride (CAS 857283-65-9)
- 2-(2-Aminoethyl)isoindolin-1-one hydrochloride (CAS 1179363-41-7)
- Ethyl (2S,5S)-5-phenylpyrrolidine-2-carboxylate (CAS 166941-66-8)
- N-(4-fluorophenyl)piperidine-4-carboxamide (CAS 883106-56-7)
- Oxiconazole Nitrate (CAS 64211-46-7)
- 4-Chloro-N-(cyclopropylmethyl)aniline hydrochloride (CAS 1785761-10-5)
- Serpent Peptide (CAS 823202-99-9)
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