5-Chloro-N-(3,5-dimethoxybenzyl)-2,4-difluoro-N-(5-fluorothiazol-2-yl)benzenesulfonamide CAS 2448268-06-0
| CAS No. | 2448268-06-0 |
| Molecular Formula | C18H14ClF3N2O4S2 |
| Molecular Weight | 478.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 478.89 g/mol gives 5-Chloro-N-(3,5-dimethoxybenzyl)-2,4-difluoro-N-(5-fluorothiazol-2-yl)benzenesulfonamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Chloro-N-(3,5-dimethoxybenzyl)-2,4-difluoro-N-(5-fluorothiazol-2-yl)benzenesulfonamide (CAS 2448268-06-0) is a high-purity analytical reference standard with the molecular formula C18H14ClF3N2O4S2 and a molecular weight of 478.89 g/mol.
The molecular framework of 5-Chloro-N-(3,5-dimethoxybenzyl)-2,4-difluoro-N-(5-fluorothiazol-2-yl)benzenesulfonamide (C18H14ClF3N2O4S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H14ClF3N2O4S2 |
| Molecular Weight | 478.89 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Chloro Standards
- 5-Chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(5-fluorothiazol-2-yl)benzenesulfonamide (CAS 1788874-30-5)
- (R)-4-[[3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl]sulfonyl]-N,N-dimethylbenzamide (CAS 252017-04-2)
- 3-(4-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-((2,4-difluorophenyl)sulfonyl)-1H-pyrazole (CAS 477710-96-6)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methyl-N-((2-methyl-3-phenylisoxazolidin-5-yl)methyl)methanesulfonohydrazide (CAS 339276-50-5)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(1E)-[3-(trifluoromethyl)phenyl]methylidene]piperidine-4-carbohydrazide (CAS 338761-42-5)
- 3-((2-Chloro-6-fluorobenzyl)thio)-5-(((2,6-dichlorobenzyl)sulfinyl)methyl)-4-methyl-4H-1,2,4-triazole (CAS 344271-85-8)
- 3-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-5-{[(2,4-dichlorophenyl)methanesulfinyl]methyl}-4-methyl-4H-1,2,4-triazole (CAS 344272-24-8)
- N-(3-chloro-4-methylphenyl)-2-((4-(2,4-dimethylphenyl)-5-(2-hydroxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 831194-08-2)
Recommended Standards
- 4-(4-Chlorophenyl)-2-(2,3-dimethylphenoxy)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 303984-58-9)
- 6-Amino-7-((4-chlorophenyl)sulfonyl)-5-(4-ethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile (CAS 691396-68-6)
- Isochlortetracycline (CAS 514-53-4)
- Empagliflozin Impurity 280 (CAS 2562349-63-5)
- Selenophen-2-ylboronic acid (CAS 35133-86-9)
- 2-(Difluoromethyl)-4-nitro-3-(trifluoromethoxy)pyridine-6-sulfonyl chloride (CAS 1805218-94-3)
- tert-Butyl ((S)-1-amino-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)carbamate (CAS 2713439-69-9)
- 6-(4-(6-Chloropyridin-2-yl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione (CAS 339012-75-8)
- 2-((1,3,4-Thiadiazol-2-yl)thio)-1-(2,5-dimethylphenyl)ethan-1-one (CAS 867302-88-3)
- Methyl 1-aminocyclooctane-1-carboxylate (CAS 183429-68-7)
- 4-Bromo-3-formylphenylboronic acid (CAS 1451393-33-1)
- (Z)-3-Methyl-2-penten-4-yn-1-ol (CAS 6153-05-5)
- 2-Methylquinoline-7,8-diol (CAS 10529-35-8)
- Calcitonin N-Terminal Flanking Peptide (human) (CAS 118277-01-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com