Dotinurad Impurity 75 CAS 24526-98-5
| CAS No. | 24526-98-5 |
| Molecular Formula | C16H10Cl4O5 |
| Molecular Weight | 424.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dotinurad Impurity 75 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dotinurad Impurity 75 (CAS 24526-98-5, C16H10Cl4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H10Cl4O5, Dotinurad Impurity 75 contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 424.06 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H10Cl4O5 |
| Molecular Weight | 424.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
Related Dotinurad Standards
- Dotinurad Impurity 8 (CAS 1285573-40-1)
- Dotinurad Impurity 197 (CAS CATO-C4X-2494197)
- Dotinurad Impurity 34 (CAS CATO-C4X-249434)
- Dotinurad Impurity 70 (CAS CATO-C4X-249470)
- Dotinurad Impurity 236 (CAS CATO-C4X-2494236)
- Dotinurad Impurity 252 (CAS CATO-C4X-2494252)
- Dotinurad Impurity 237 (CAS CATO-C4X-2494237)
- Dotinurad Impurity 230 (CAS CATO-C4X-2494230)
Recommended Standards
- Diploicin (CAS 527-93-5)
- 5,6-Difluoro-4,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[c][1,2,5]thiadiazole (CAS 1295502-63-4)
- 6-(2,5-Dibromophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid (CAS 36991-81-8)
- Benzbromarone Impurity 22 (CAS CATO-C4X-225022)
- Neratinib Impurity 16 (CAS 1376619-94-1)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
- Lidocaine EP Impurity H (CAS 1131-01-7)
- N-(3-ethyl-4-fluorophenyl)thietan-3-amine (CAS 1863406-60-3)
- 2,6-Dichlorosyringaldehyde (CAS 76330-06-8)
- 4-(3-(Benzo[d][1,3]dioxol-5-yl)-1,2,4-oxadiazol-5-yl)-2-(3-chlorophenyl)phthalazin-1(2H)-one (CAS 1291862-60-6)
- 6,7,9,10,12,13,15,16,23,24,26,27,29,30,32,33-Hexadecahydrodibenzo[b,q][1,4,7,10,13,16,19,22,25,28]decaoxacyclotriacontine (CAS 17455-25-3)
- 2-[(Piperidin-4-yl)methoxy]-6-(trifluoromethyl)pyridine hydrochloride (CAS 2097937-66-9)
- Methyl 3-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}-3-oxopropanoate (CAS 499796-74-6)
- Peptide 433 (CAS CATO-CPTD788433)
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