Crisaborole Impurity 42 CAS 1260761-47-4
| CAS No. | 1260761-47-4 |
| Molecular Formula | C7H7BrO2 |
| Molecular Weight | 203.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Crisaborole Impurity 42 (CAS 1260761-47-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H7BrO2 and a molecular weight of 203.03 g/mol.
Crisaborole Impurity 42 (C7H7BrO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7BrO2 |
| Molecular Weight | 203.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 41 (CAS 2737-19-1)
- Crisaborole Impurity 1 (CAS 20035-32-9)
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 45 (CAS 2973-80-0)
- Crisaborole Impurity 48 (CAS 22532-61-2)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
Recommended Standards
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- 4-Bromo-1-ethyl-1h-pyrazole-3-carbaldehyde (CAS 1001519-36-3)
- Phloroglucinol Impurity 15 (CAS 95-56-7)
- Tolvaptan Impurity 76 (CAS 2458812-63-8)
- Pemafibrate Impurity 8 (CAS CATO-C4X-29038)
- 18:1 propargyl PC (CAS 1830366-41-0)
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- 3-[2-(tert-Butyl)-4-chlorophenoxy]azetidine (CAS 1146960-45-3)
- 5-Bromo-3,3-diethylindoline (CAS 1315366-11-0)
- DPP610-Br (CAS 1423138-95-7)
- Peptide 74 (H-8545.0500) (CAS 132116-39-3)
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