Tofacitinib Impurity 205 CAS 2459302-87-3
| CAS No. | 2459302-87-3 |
| Molecular Formula | C26H26Cl2N8 |
| Molecular Weight | 521.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Tofacitinib Impurity 205 (CAS 2459302-87-3), a pharmacopoeial impurity reference standard (molecular formula C26H26Cl2N8, MW 521.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C26H26Cl2N8, Tofacitinib Impurity 205 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 521.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H26Cl2N8 |
| Molecular Weight | 521.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Tofacitinib Standards
- Tofacitinib Impurity 213 (CAS CATO-C4X-1079213)
- Tofacitinib Impurity 173 (CAS CATO-C4X-1079173)
- Tofacitinib Impurity 222 (CAS CATO-C4X-1079222)
- Tofacitinib Impurity 49 (CAS 2459302-78-2)
- Tofacitinib Impurity 35 (CAS CATO-C4X-107935)
- Tofacitinib Impurity 36 (CAS CATO-C4X-107936)
- Tofacitinib Impurity 56 (CAS 923036-30-0)
- Tofacitinib Impurity 64 (CAS 2504210-40-4)
Recommended Standards
- 1-(Tert-butyldimethylsilyl)-5-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridine (CAS 754214-65-8)
- 2-((3,4-Dichlorobenzyl)thio)-4-(3,4-dimethoxyphenyl)-6-(p-tolyl)nicotinonitrile (CAS 444156-97-2)
- Mometasone Furoate (CAS 83919-23-7)
- 1,2-Bis(1-(7-chloroquinazolin-4-yl)piperidin-4-yl)ethane (CAS 52791-50-1)
- Bumetanide Impurity 111 (CAS CATO-C4X-1986111)
- Lacidipine impurity 9 (CAS CATO-C4X-16719)
- Deferiprone Impurity 6 (CAS CATO-C4X-30486)
- 2-[2-(benzyloxy)phenyl]ethan-1-ol (CAS 56052-43-8)
- Tert-butyl (2r)-2-amino-7-azabicyclo[2.2.1]heptane-7-carboxylate (CAS 1354973-35-5)
- (S)-Ethyl 2-amino-3-hydroxy-2-methylpropanoate (CAS 1315053-72-5)
- (4-((4-(Tert-butyl)phenyl)sulfonyl)piperazin-1-yl)(4-nitrophenyl)methanone (CAS 439094-02-7)
- N-(3,5-dimethylphenyl)hydrazinecarbothioamide (CAS 656815-74-6)
- Methyl 3-(1,3-dimethyl-1H-pyrazol-4-yl)propiolate (CAS 1354706-93-6)
- Uremic Pentapeptide (CAS 71494-20-7)
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