Tofacitinib Impurity 173 CAS CATO-C4X-1079173
| CAS No. | CATO-C4X-1079173 |
| Molecular Formula | C26H28N8O2S |
| Molecular Weight | 516.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 173.
Tofacitinib Impurity 173 (CAS CATO-C4X-1079173) is a certified pharmaceutical impurity reference standard with the molecular formula C26H28N8O2S and a molecular weight of 516.62 g/mol.
Structurally, Tofacitinib Impurity 173 (C26H28N8O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 516.62 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H28N8O2S |
| Molecular Weight | 516.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 205 (CAS 2459302-87-3)
- Tofacitinib Impurity 213 (CAS CATO-C4X-1079213)
- Tofacitinib Impurity 222 (CAS CATO-C4X-1079222)
- Tofacitinib Impurity 35 (CAS CATO-C4X-107935)
- Tofacitinib Impurity 36 (CAS CATO-C4X-107936)
- Tofacitinib Impurity 56 (CAS 923036-30-0)
- Tofacitinib Impurity 64 (CAS 2504210-40-4)
- Tofacitinib Impurity 49 (CAS 2459302-78-2)
Recommended Standards
- m-PEG11-OH (CAS 2168540-65-4)
- Canagliflozin Impurity 89 (CAS CATO-C4X-112389)
- Micrandilactone B (CAS 861888-12-2)
- Mupirocin EP Impurity A (CAS 40980-51-6)
- Bepotastine Impurity 25 (CAS CATO-C4X-183925)
- Raltitrexed Impurity 5 (CAS 4282-31-9)
- Olopatadine Impurity 48 (CAS CATO-C4X-171848)
- 1-(2-butoxyphenyl)ethanone (CAS 7197-02-6)
- 2,4-Difluoro-6-nitroso-1,3-benzenediol (CAS 851128-76-2)
- 2,6-Difluoro-4-nitrobenzoic acid (CAS 196194-57-7)
- 3-(3-Chloro-1H-1,2,4-triazol-5-yl)propan-1-ol hydrochloride (CAS 1279219-22-5)
- Ilaprazole Impurity 102 (CAS CATO-C4X-1130102)
- 1-Phenyl-2-(m-tolyl)ethane (CAS 34403-06-0)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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